老年2型糖尿病患者认知功能障碍与炎症因子水平的相关性

The correlation between cognitive impairment and inflammatory factor ’ s levels elderly patients with type 2 diabetes mellitus

目的：探讨老年2型糖尿病患者认知功能障碍与炎症因子的相关性。方法将40例老年2型糖尿病伴认知功能障碍患者设为A组，40例无认知功能障碍的老年2型糖尿病患者设为B组，抽取同期进行健康体检的年龄≥60岁的健康志愿者38例设为C组。采用简易精神状态量表、蒙特利尔认知评估量表、韦氏成人智力量表评定认知功能，检测3组各项生化指标和炎症因子水平，并进行相关分析。结果 A组和B组患者空腹血糖、糖化血红蛋白、超敏C反应蛋白、白细胞介素-6、肿瘤坏死因子水平均显著高于C组（ P＜0．05或0．01），且A组均显著高于B组（ P＜0．05或0．01）；A组简易精神状态量表、蒙特利尔认知评估量表、韦氏成人智力量表总分及简易精神状态量表视空间与执行功能、注意、延迟回忆和定向因子分均显著低于B组和C组（P＜0．01）；A组认知功能障碍与糖化血红蛋白、白细胞介素-6、肿瘤坏死因子水平显著相关（ P＜0．05或0．01）。结论糖化血红蛋白、白细胞介素-6、肿瘤坏死因子是2型糖尿病合并认知功能障碍的重要影响因素。

Objective To investigate the correlation between cognitive impairment and inflammatory factor’s levels elderly patients with type 2 diabetes mellitus （T2DM ） .Methods Forty T2DM elderly patients with cognitive impairment were assigned to group A ,40 ones without to B ,and 38 healthy volunteers aged≥60 selected from persons experiencing health examination in corresponding period to C .Cognitive functions were assessed with the Mini-mental State Examination （MMSE） ,Montreal Cognitive Assessment （MoCA） and Wechsler Adult Intelligence Scale （WAIS） ,all biochemical indicators and inflammatory factors’ levels of three groups detected ,and correlation analyses carried out .Results Levels of serum FBG , HbAlc ,hs-CRP ,IL-6 ,TNF-α of group A and B were all significantly higher than those in C （P〈0 .05 or 0 .01） and so were those in A than in B （P〈0 .05 or 0 .01）;the total score of the MMSE ,MoCA and WAIS as well as visual space ,executive function ,attention ,delayed recall and orientation score of the MMSE were all significantly lower in groups A than in B and C （P〈0 .01）;cognitive dysfunction was sig-nificantly related to HbAlc ,hs-CRP ,IL-6 ,TNF-α levels in group A （P〈0 .05 or 0 .01） .Conclusion HbAlc ,IL-6 and TNF-α are important influencing factors of type 2 diabetes mellitus complicated with cognitive dysfunction .