氨磺必利对精神分裂症患者临床疗效及生活质量的影响

Amisulpride’s influence on clinical efficacy and quality of life of schizophrenics

目的：探讨氨磺必利对精神分裂症患者临床疗效及生活质量的影响。方法将125例精神分裂症患者随机分为两组，分别口服氨磺必利和利培酮治疗，观察24周。采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应，生活质量综合评定问卷评定生活质量。结果治疗4周末起两组阳性与阴性症状量表评分均较治疗前显著降低（P＜0．01），氨磺必利组治疗8周末起阴性症状因子分显著低于利培酮组（ P＜0．05或0．01），治疗24周末生活质量综合评定问卷躯体功能、心理功能、社会功能维度分均显著高于利培酮组（P＜0．01）。氨磺必利组月经紊乱、血脂异常、血糖异常等不良反应发生率显著低于利培酮组（P＜0．05）。结论氨磺必利与利培酮治疗精神分裂症疗效显著且相当，但氨磺必利在改善阴性症状及患者生活质量方面效果更好，安全性更高。

Objective To explore amisulpride’s influence on clinical efficacy and quality of life of schizo-phrenics .Methods A total of 125 chizophrenics were randomly divided into two groups ,they respectively took orally amisulpride and risperidone for 24 weeks .Efficacies were assessed with the Positive and Negative Syndrome Scale （PANSS） ,adverse reactions with the Treatment Emergent Symptom Scale （TESS） and qualities of life with the Generic Quality of Life Inventory-74 （GQOLI-74） .Results Since the end of the 4th week the PANSS scores of both groups lowered more significantly compared with pretreatment （P〈0 .01） ,since the end of the 8th week negative symptoms scores were significantly lower （P〈0 .05 or 0 .01） and at the end of 24th week physical ,mental and social function score of the GQOLI-74 higher （P〈0 .01）in amisulpride than risperidone group .The incidences of menstrual disorder ,abnormal blood lipid and glucose were significantly lower in amisulpride than risperidone group （P〈 0 .05） .Conclusion both amisulpride and risperidone have an evident in schizophrenia ,but amisulpride improves negative symptoms and quality of life better and has higher safety .