丁丙诺啡治疗海洛因依赖戒断综合征临床疗效分析

The efficacy of buprenorphine in heroin dependence withdrawal syndrome

目的：探讨丁丙诺啡治疗海洛因依赖戒断综合征的临床疗效。方法将521例海洛因依赖戒断综合征患者随机分为两组，研究组舌下含服丁丙诺啡，静脉滴注氟哌啶醇＋东莨菪碱治疗，对照组口服美沙酮治疗，观察2周。对两组临床疗效进行对比分析。结果研究组有效率为95．1％，对照组为75．1％，研究组有效率显著高于对照组（χ^2＝41．99，P＜0．01）。结论舌下含服丁丙诺啡、静脉滴注氟哌啶醇＋东莨菪碱治疗海洛因依赖戒断综合征疗效显著，优于美沙酮替代治疗。

Objective To explore the efficacy of buprenorphine in heroin dependence withdrawal syndrome （HDWS） .Methods A total of 521 HDWS patients were randomly assigned to two groups ,research group was treated with sublingually buccal buprenorphine and intravenous drip of haloperidol＋scopolamine ,and control group took orally methadone for 2 weeks .Efficacies of two groups were contrastively analyzed .Results Effective rate was respectively 95 .1% in research and 75 .1% in control group ,the former significantly higher than the latter （χ^2 =41 .99 ,P〈0 .01） .Conclusion Sublingually buccal buprenorphine and intravenous drip of haloperidol ＋ scopolamine have an evident effect compared with methadone replacement therapy in HAWS .