TORCH系列病原体感染与原发性高血压的相关性研究

Correlation between series pathogen infection of TORCH and essential hypertension

目的：探讨TORCH系列病原体感染与原发性高血压的相关性研究。方法分别采集760例住院患者（年龄40～65岁）的血液，其中包括320例原发性高血压患者标本和440例对照标本，应用酶联免疫吸附试验（ELISA）检测血清TORCH系列病原体抗-IgG和抗-IgM，并进行两组间比较。结果高血压组患者人巨细胞病毒（HCMV）抗-IgG阳性率高于对照组（χ2=33.790，P=0.001），单纯疱疹病毒（HSV）抗-IgG阳性率亦高于对照组（χ2=7.786，P =0.003）。结论 HCMV和HSV感染可能是原发性高血压的重要危险因素。

Objective To explore the correlation between series pathogen infection of TORCH and essential hypertension.Methods The blood of 760 hospitalized patients （40-65 years old） were collected, which included 320 cases of essential hypertension specimens and 440 cases of the control samples. Then IgG and IgM antibodies of series pathogens of TORCH in serum were detected by enzyme-linked immunosorbent assay （ELISA）. The results of the two groups were compared, respectively.Results The positive rate of human cytomegalovirus （HCMV） IgG antibody in the group of hypertensive patients was higher than that of the control group （χ2= 33.790,P = 0.001）, and also herpes simplex virus （HSV） IgG antibody in the group of hypertensive patients was higher than that of the control group （χ2= 7.786,P = 0.003）.Conclusion The infection of HCMV, HSV may be important risk factors for essential hypertension.