翻修疗法对人工关节置换后合并感染的疗效研究

Effect of renovated therapy on the patients of arthroplasty with infection

目的探究人工关节翻修治疗对人工关节置换后合并感染的疗效。方法选取2008年3月至2013年8月自重庆市红十字会医院(江北区人民医院)和重庆市第三人民医院就诊的150例人工关节置换术后并发感染的患者,依据治疗方法的不同将患者分为翻修组和保守组;翻修组患者在常规抗感染治疗的基础上给予患者人工关节翻修治疗,保守组给予积极的常规保守抗感染治疗。结果治疗后两组患者的红细胞沉降率(ESR)、窦道形成、疼痛造成行走不便、产生轻微不适感时的负重重量、关节穿刺液细菌培养阳性例数及C-反应蛋白(CRP)水平均显著下降(P均<0.05),负重重量显著增加(P<0.05)。且翻修组效果要优于保守组(P<0.05)。结论人工关节翻修疗法可有效治疗关节置换后合并感染,明显提高患者的生活质量,建议临床积极推广实施。

Objective To explore the effect of renovated therapy on the patients of arthroplasty with infection. Methods From January 2009 to March 2012, total of 150 cases of arthroplasty with concurrent infection which came from Hospital of Chongqing Red Cross Society （Jiangbei District People＇s Hospital） and the Third People＇s Hospital of Chongqing were divided into renovation group and conservative group according to different methods of treatment. The renovation group accepted artificial joint with revision treatment on the conventional anti-infective therapy, conservative group only accepted conventional anti- infective therapy. Results After treatment, erythrocyte sedimentation rate （ESR）, sinus formation, difficulties in walking by the pain, resulting in a slight discomfort when the load weight, joint aspirate positive bacterial culture and C-reactive protein （CRP） levels were all significantly decreased （P 〈 0.05）. Load weight were significantly increased （P 〈 0.05）. After treatment renovated group was better than in the conservative group （P 〈 0.05）. Conclusions Artificial joint revision joint replacement therapy could be effective in treating post-infection, significantly improve the patient＇s quality of life, so suggested that clinical actively promote the implemetation.