伊木萨克片联合帕罗西汀治疗早泄的临床效果研究

Clinical effect of Yimusake tablets combined with paroxetine in the treatment of premature ejaculation

目的对比研究单独使用伊木萨克片或帕罗西汀的治疗方案以及两种药物联合使用的治疗方案治疗早泄(PE)的临床效果。方法 136例患者,分为伊木萨克片组39例,帕罗西汀组47例,联合组50例,分别以口服伊木萨克片3片/d,帕罗西汀20 mg/d,联合使用两种药物治疗早泄,疗程均为30 d,对比三种治疗方案的患者在治疗前后的阴道内射精潜伏时间(IELT)和性伴侣满意程度评分结果,同时统计各治疗方案的副作用。结果各方案治疗后的IELT明显提高,其中以联合组最为明显,而治疗后性伴侣满意度评分差异无统计学意义(P>0.05)。三种治疗方案以联合组治愈率为最高,达到82.0%。差异有统计学意义(P<0.05),结论联合使用伊木萨克片、帕罗西汀治疗PE有较高的治愈率,能明显提高患者的IELT和其性伴侣的满意程度,可予以临床推广。

Objective To compare the clinical effect of Yimusake tablets or paroxetine, as well as the two drugs used in combination in the treatment of premature ejaculation（PE）. Methods Divided 126 patients into Yimusake tablets group（39 cases）, paroxetine group（47 cases）, combination group（50 cases）, respectively given Yimusake tablets 3 tablets per day, paroxetine 20 mg/d, and the two drugs in combination to cure the PE patients, all drugs taken orally, the course of treatment was 30 d, comparing the intravaginal ejaculatory latency time（IELT） and sexual partner satisfaction score results of PE patients who received the three treatment programs, at the same time recorded the side effects of each treatment programs. Results After the treatment, the IELT significantly improved, and the most obvious group was combination group, but the satisfaction scores of sexual partners in the three groups had no significant difference, the cure rate of combination group was the highest in three groups, reaching 82.0%（P〈0.05）. Conclusion The combined use of Yimusake tablets and paroxetine have a higher cure rate in the treatment of PE and can significantly improve the patient＇s IELT, so it can be clinical used widely.