3%高渗盐水联合雾化吸入治疗毛细支气管炎临床疗效观察

The application of 3% hypertonic saline combined with Terbutaline and Pulmicortin the treatment of bronchiolitis

目的探讨3%高渗盐水联合布地奈德、特布他林雾化吸入治疗毛细支气管炎临床疗效。方法将80例住院毛细支气管炎患儿分成对照组、实验组各40例,对照组使用特布他林、布地纳德雾化吸入,1小时后给予生理盐水4ml雾化吸入,实验组使用布地纳德、特布他林雾化吸入,1小时后给予3%高渗盐水4 ml雾化吸入,比较两组,喘息、咳嗽、哮鸣音消失时间及住院时间,入院时肺功、3天时肺功、7天时肺功。结果实验组在喘息、咳嗽、哮鸣音消失时间及住院时间方面与对照组相比,明显缩小,具有统计学意义,实验组3天时肺功改善情况明显高于对照组,具有统计学意义,7天时肺功改善情况基本相同,无统计学意义。结论 3%高渗盐水联合布地纳德、特布他林雾化吸入治疗毛细支气管炎能有效的缩短治疗时间及短效改善患儿肺功能。

Objective To investigate the clinical efficacy of 3% hypertonic saline combined with Terbutaline and Pulmicortin the treatment of bronchiolitis. Methods 80 cases of hospitalized bronchiolitis children were randomly divided into treatment and control group two,40 cases in each group. Infants in control group were administrated by inhalation with Terbutaline and Pulmicort,and one hour later,the infants were administrated by inhalation with 0. 9% saline. In treatment group,the infants were administrated by inhalation with terbutaline and Pulmicort,but the infants were administrated by inhalation with 3% hypertonic saline one hour. Wheezing,coughing and wheezing rale remission time,days of hospitalization of the two groups were compared. Lung functionof the two groups was compared too. Results Wheezing,coughing and wheezing rale remission time and days of hospitalization of the treatment group were significantly less than the control group.Lung function of the treatment group was significantly better than the control group at the third day post treatment,and the difference of lung function between the two groups was not statistically significant at the seventh day post treatment. Conclusions Inhalation of 3% hypertonic saline combined with Terbutaline and Pulmicort can improve symptoms of infants with bronchiolitis,shorten the course of therapy and improve lung function.