血清降钙素原和C-反应蛋白测定在尿路感染中的临床应用

Clinical application of serum procalcitonin and C-reactive protein detection in urinary tract infection

目的：探讨血清降钙素原（PCT）和C-反应蛋白（CRP）测定在尿路感染中的应用价值。方法：选择上尿路感染患者45例、下尿路感染患者40例及无尿路感染的健康查体者45例作为研究对象，分别检测各组血清PCT、CRP及血、尿白细胞（WBC）水平，同时根据培养鉴定结果将尿路感染患者再次分为细菌及真菌感染组，并对上述指标进行比较。结果：上、下尿路感染组患者血、尿WBC及血清PCT、CRP均明显高于对照组，差异有统计学意义（P＜0.05）；上尿路感染组患者血清PCT、CRP水平均明显高于下尿路感染组，差异有统计学意义（P＜0.05）；细菌、真菌引起的尿路感染组患者血、尿WBC及血清PCT、CRP水平组间无统计学差异（P＞0.05）；PCT诊断敏感度为90.59%、特异度为93.33%。结论：血清PCT、CRP 可作为诊断及定位尿路感染的有效指标，但PCT 具有更高的敏感度和特异度。

Objective： To investigate the diagnostic value of serum procalcitonin （PCT） and C-reactive protein （CRP） in urinary tract infection.Methods：45 patients with upper urinary tract infections, 40 patients with urinary tract infections and 45 cases of healthy people without urinary tract infection were studied, the serum PCT, CRP and blood, urine white blood cell （WBC） levels were detected, while they were divided into groups of bacteria and fungal infections according to the results of the culture and identification.Results：The blood and urinary WBC and serum PCT, CRP in patients with urinary tract infection were significantly higher than the control group, the difference was of statistically significant （P〈0.05）; The serum PCT and CRP in upper urinary tract infection group were significantly higher than the lower urinary tract infection group（P〈0.05）; The blood and urinary WBC and serum PCT, CRP in patients with bacterial and fungal urinary tract infections were no of statistically significant （P〈0.05）; the PCT diagnostic sensitivity was 90.59% and specificity was 93.33% .Conclusions：The serum PCT and CRP can be used as an effective indicator to locate and diagnose urinary tract infection, but PCT has a higher sensitivity and specificity.