牙龈卟啉单胞菌菌体表面毒力因子及其致病性研究进展

Research progress in thallus surface virulence factors and pathogenesis of Porphyromonas gingivalis

牙周炎是以牙槽骨吸收和牙周袋形成为主要病理改变和临床体征的慢性感染性疾病,菌斑微生物是其主要的始动因子。大量研究证实,牙龈卟啉单胞菌(Porphyromonas gingivalis,P.gingivalis)是各种牙周炎,尤其是慢性牙周炎最主要的病原菌。本文主要对P.gingivalis外膜的致病结构及其理化特征做一综述,以期对牙周炎的治疗、防治及相关疫苗研发有所裨益。

Alveolar resorption and periodontal pocket formation are the main pathologic change and clinical sign of peri- odontitis, which is a chronic infectious disease. Dental plaque is the main pathogenic factor. Multiple researches have proved that Porphyromortas gingivalis （P.gingivalis） is the main pathogenic bacteria of a variety of periodontitis, especial- ly the chronic periodontitis. This article describes the structure and physiochemical characteristics of outer membrane protein of P.gingivalis, in order to be helpful to the prevention and treatment of periodontitis and the vaccine research and development.