清肠合剂保留灌肠治疗肝硬化轻微型肝性脑病的临床研究

Clinical Research on Hepatic Encephalopathy of Liver Cirrhosis Treated with Qingchang Mixture(清肠合剂)

目的:观察清肠合剂保留灌肠治疗肝硬化轻微型肝性脑病的疗效。方法:选取本院住院的肝硬化轻微型肝性脑病患者90例,随机分为3组,每组30例,各组均予以常规西医治疗,治疗组另加用清肠合剂保留灌肠;对照1组加用拉克替醇(乳果糖)口服;对照2组仅以常规西医治疗。3组疗程均为15天。疗程结束后对患者的症状体征、相关能力、肝功能、凝血功能、血氨水平以及内毒素水平等指标进行统计分析和比较。结果:3组患者治疗后在症状体征、相关能力方面均有好转。3组均可降低TBil,但清肠合剂治疗组效果更优;3组均可缩短PT值、增加ALB含量。3组均可降低血氨和内毒素值,但治疗组效果更佳。结论:清肠合剂保留灌肠是治疗肝硬化轻微型肝性脑病的有效方法。

Objective： To investigate the effects of Qingchang mixture retention enema on minim hepatic encephalopathy of liver cirrhosis patients. Methods： 90 liver cirrhosis patients with mild hepatic encephalopathy were divided into 3 groups： control group 1,control group 2 and treatment group,besides the regular treatment,the treatment group was given Qingchang mixture retention enema,the control group 1 was given lactulose po,the treatment course was 15 days. The digital connection exam,digital symbol exam,liver function,coagulation function,blood ammonia level and endotoxin level were determined and compared,analysised. Results： All groups had better performance on the digital connection exam and digital symbol exam,and the level of PT and ALB. The level of TBil,PT,blood ammonia and endotoxin were decreased in all groups,but the treatment group had better results. Conclusion： Qingchang mixture retention enema is an effective method for treating hepatic encephalopathy of liver cirrhosis.