食管鳞状细胞癌中Bax、XIAP与细胞凋亡的关系

The relationship between Bax,XIAP and cell apoptosis in esophageal squamous cell carcinoma

目的研究食管鳞状细胞癌中Bax、XIAP的表达及其与细胞凋亡的关系。方法采用免疫组织化学SABC法检测Bax与XIAP在食管鳞癌与正常食管黏膜中的表达。结果 Bax蛋白在正常食管粘膜中的表达高于食管鳞癌(P<0.05),XIAP在食管鳞癌中的表达高于正常食管黏膜,差异具有统计学意义(P<0.05);Bax与XIAP的表达与食管鳞癌的组织学分级与临床病理分期无关。结论 Bax与XIAP可能通过细胞凋亡参与食管鳞癌的发生发展,二者的异常表达对食管鳞癌的侵袭与预后的判断具有一定的参考价值。

Objective To research the expression of Bax and XIAP as well as the relationship between Bax, XIAP and cell apoptosis in esophageal squamous cell carcinoma. Methods The expression of Bax and XIAP was detected in esophageal squamous cell carcinoma and normal esophageal mucosa tissues by SABC immunohistochemical technology. Results The expression of Bax protein in normal esophageal mucosa tissues was higher than that of esophageal squamous cell carcinoma （P〈0.05）; The expression of XIAP protein in esophageal squamous cell carcinoma was higher than that of normal esophageal mucosa tissues （P〈0.05）, The difference is statistically significant; There was no correlations between the expression of Bax and XIAP in esophageal squamous cell carcinoma and the histological classification and clinical pathologic stage of the esophageal squamous cell carcinoma. Conclusion Bax and XIAP may take part in the incidences and development of esophageal squamous cell carcinoma by cell apoptosis; The abnormal expression to invasion and prognosis judgement of esophageal squamous carcinoma has a certain reference value.