维持血液透析患者丙型肝炎感染调查研究以及感染相关因素分析

Clinial study of the hepatitis C virus infection and the rsik factors of the infection in manintenance hemodialysis patients

目的 调查研究维持血液透析患者丙型肝炎感染情况以及分析其感染发病的相关危险因素.方法 选取我院2008年1月-2012年3月在我院进行维持血液透析治疗的慢性肾功能不全患者250例,对照选取人群自愿献血者100例,对比分析两组HCV发病率,同时对透析患者的危险因素进行Logistic回归分析.结果 透析组患者HCV感染阳性率为28.0％,明显高于对照组的2.0％（P＜0.05）,Logistic回归显示年龄、输血情况、白蛋白、更换透析单位次数、糖尿病、透析时间均与HCV感染相关,OR值均＞1,表明均为正相关.结论 维持血液透析患者患丙型肝炎率明显高于正常人群,年龄、输血情况、白蛋白、更换透析单位次数、糖尿病、输血时间是其感染HCV的危险因素,应在临床应用采取措施预防.

Objective To study the prevalence of hepatitis C virus （HCV） infection and the risk factors of the infection for manintenance hemodialysis patients.Methods 250 manintenance hemodialysis patients were collected in our hosptial from January 2008 to March 2012 as the observation group.100 cases of voluntary blood donors were selected as the control group.The risk factors of the infection and the HCV infection rate of the two groups were compared and analyzed.Results The HCV infection rate of the observation group was 28.0%,The HCV infection rate of the control group was 2.0%,The HCV infection rate of the observation group was higher than that of the control group （P 〈 0.05）.Logistic analysis showed that Age,blood transfusion,albumin,replace the number of dialysis units,diabetes and blood transfusion time were positively correlated with HCV infection （OR 〉 1）.The HCV infection rate of manintenance hemodialysis patients was higher than the normal people （P 〈 0.05）.Conclusions Age,blood transfusion,albumin,replace the number of dialysis units,diabetes and blood transfusion time were the risk factors of the infection for manintenance hemodialysis patients,which should be taken measures to prevent.