急性呼吸道感染住院患儿RSV和ADV与病情严重程度相关性研究

Relationship between RSV and ADV with illness condition in children with acute respiratory tract infections

目的 通过对呼吸道合胞病毒（RSV）及腺病毒（ADV）临床检测阳性率来评价儿童急性呼吸道感染病情严重程度的相关性分析.方法 将82例患急性呼吸道感染的儿童（感染组）及30例健康儿童（健康组）作为观察对象,比较两组RSV和ADV阳性率;同时根据感染严重程度,将感染组患儿分为28例的非肺炎组、33例的普通肺炎组及21例的重症肺炎组,对比三组间RSV和ADV阳性率.此外,对感染组患儿中RSV和ADV阳性率与感染严重程度、血常规白细胞计数（WBC）、中性粒细胞百分比（N％）及淋巴细胞百分比（L％）的相关性.结果 感染组RSV和ADV阳性率明显高于健康组（P ＜0.05）,而不同严重程度感染组中,以重症肺炎组RSV和ADV阳性率最高（P＜0.05）,同时感染组中,RSV和ADV阳性率与患者的感染严重程度存在显著的直线相关性,但与WBC、N％及L％无直线相关性.结论 RSV和ADV阳性率可作为评价急性呼吸道感染患儿病情严重程度的指标.

Objective To investigate the correlation of respiratory syncytial virus （RSV） and adenovirus （ADV） with illness condition by detecting positive rate.Methods 82 children with acute respiratory tract infections were collected as infection group and 30 healthy children were collected as healthy group.RSV and ADV were detected by PCR and the positive rate was compared and analyzed.Infection group was divided into no pneumonia groups （28 cases）,common pneumonia group （33 cases） and severe pneumonia group （21 casese）.WBC count,neutrophilic granulocyte percentage （N%） and T lymphocytes percentage （L%） were tested and analyzed.Results The RSV and ADV positive rate of infection group were higher than healthy group （P 〈0.05）.The RSV and ADV positive rate of severe pneumonia group were higher than no pneumonia groups or common pneumonia group （P 〈 0.05）.There was linear correlation between RSV and ADV positive rate and illness condition.RSV and ADV positive rate had no correlation with WBC count,neutrophilic granulocyte percentage （N%） and T lymphocytes percentage （L%）.Conclusions RSV and ADV positive rate can be used as index for evaluating the illness condition.