鱼油脂肪乳联合替吉奥和奥沙利铂治疗进展期胃癌的临床观察

Clinical efficacy of ω-3 polyunsaturated fatty acid combined with SOX regimen for the treatment of advanced gastric cancer

目的探讨鱼油脂肪乳联合替吉奥+奥沙利铂(SOX方案)治疗进展期胃癌的临床疗效和不良反应。方法 70例进展期胃癌的患者随机分为试验组和对照组,每组35例。试验组患者采用鱼油脂肪乳联合SOX方案新辅助化疗,对照组患者单用奥沙利铂+希罗达(XELOX方案)新辅助化疗,2个周期后比较两组患者的临床疗效和化疗后不良反应。结果试验组和对照组患者的治疗有效率分别为65.7%和48.6%,两组比较差异有统计学意义(P<0.05)。试验组患者在卡氏评分和不良反应方面均优于对照组,差异有统计学意义(P<0.05)。结论鱼油脂肪乳联合SOX方案治疗进展期胃癌安全可靠,提高了临床疗效和患者的生存质量,不良反应较轻。

Objective To investigate the clinical efficacy of ω-3 polyunsaturated fatty acid combined with SOX regimen（ S-1 plus oxaliplatin） for the treatment of advanced gastric cancer. Methods A total of 70 cases of patients with advanced gastric cancer were selected and randomly divided into observation group（ 35 cases） and control group（ 35 cases）. The observation group and control groups received ω-3 polyunsaturated fatty acid？ combined with SOX regimen and XELOX regimen,respectively. The clinical efficacy and adverse effect were compared between the two groups after at least two consecutive courses. Results All patients were evaluated for efficacy and safety. The response rate（ RR） of observation group（ 65. 7%） was significantly higher than that of control group（ 48. 6%,P〈0. 05）. The treatment related toxicities were mild and manageable in both groups. The rates of myelosuppression and gastrointestinal reaction in observation group were significantly lower than those of control group（ P〈0. 05）. Conclusion ω-3polyunsaturated fatty acid combined with SOX regimen is effective,safe and can improve quality of life in patients with advanced cancer.