鼓膜置管术与鼓室注药治疗鼻咽癌放疗后分泌性中耳炎的疗效分析

Clinical efficacy of tympanic membrane indwelling catheter and tympanic irrigation treatment for secretory otitis media patients with nasopharynx cancer after radiotherapy

目的探讨鼓膜置管术与鼓室注药治疗鼻咽癌放疗后分泌性中耳炎的临床疗效。方法 2010年4月至2012年1月间收治的鼻咽癌放疗后分泌性中耳炎患者128例,按治疗方式分为对照组(n=64)和试验组(n=64)。对照组采用盐酸氨溴索鼓室注药,试验组采用鼓膜置管术。比较两组患者的临床疗效、言语频率及并发症发生率。结果对照组和试验组患者的治疗总有效率分别为65.6%和87.5%,试验组患者的疗效明显优于对照组,差异有统计学意义(χ2=4.267,P<0.05)。对照组和试验组患者的并发症发生率分别为50.0%和15.6%,试验组患者的并发症发生率明显低于对照组,差异有统计学意义(χ2=8.576,P<0.05)。试验组患者的言语频率明显低于对照组,差异有统计学意义(t=3.202,P<0.05)。结论采用鼓膜置管术治疗鼻咽癌放疗后分泌性中耳炎的临床疗效优于鼓室注药。

Objective To explore the clinical efficacy of tympanic membrane indwelling catheter and tympanic irrigation treatment for secretory otitis media patients with nasopharynx cancer after radiotherapy. Methods A total of 128 secretory otitis media patients with nasopharynx cancer after radiotherapy were randomly divided into two groups,64 cases in each group. Tympanic membrane indwelling catheter was used in the treatment group and ambroxol hydrochloride tympanic irrigation was used in the control group. The clinical efficacy,words frequency and complication were compared between the two groups. Results The efficiency of clinical treatment was 87. 5% in the treatment group,as compared with 65. 6% in the control group,and that of the treatment group were significantly higher than that of the control group（ χ^2= 4. 267,P〈0. 05）. The rate of complication was 15. 6% in the treatment group,as compared with of 50. 0% in the control group,and that of the treatment group were significantly lower than that of the control group（ χ^2=8. 576,P〈0. 05）. Words frequency of the treatment group were significantly lower than that of control group. The difference was statistically significant（ t = 3. 202,P〈0. 05）. Conclusion Using tympanic membrane indwelling catheter treatment for secretory otitis media patients with nasopharynx cancer after radiotherapy is superior to tympanic irrigation.