寻常型银屑病与HLA-DQB1等位基因的关联

Psoriasis vulgaris and HLA-DQB1 allelic gene

目的探讨HLA-DQB1等位基因与寻常型银屑病的关联。方法采用聚合酶链反应(PCR)/序列特异性引物(SSP)技术检测30例汉族寻常型银屑病患者和同一地区无血缘关系的健康汉族人群228例的HLA-DQB1等位基因。结果寻常型银屑病患者组中DQB1*0602等位基因频率比对照组明显增高(P<0.01,RR=3.24),而DQB1*0303和DQB1*0601等位基因频率均低于对照组,但无统计学差异(P>0.05)。结论寻常型银屑病与DQB1*0602等位基因的关联,可为揭示寻常型银屑病发病的免疫遗传学机制提供新线索。

Objective To study the correlation between psoriasis vulgaris（ PV） and HLA-DQB1 allelic gene. Methods HLADQB1 allelic genes were detected by means of polymerase chain reaction / sequence specific primers（ PCR / SSP） in 30 PV patients and 228 without-kinship healthy Chinese. Results The frequency of DQB1＊ 0602 allelic gene was obviously higher in the PV patients than in the healthy controls（ P〈0. 01,RR = 3. 24）. The frequencies of DQB1＊ 0303 and DQB1＊ 0601 allelic genes were both lower in the PV patients than in the healthy controls,but the differences did not reach significance. Conclusion PV and HLA-DQB1＊ 0602 allelic gene are genetically related each other,which provides a new clue to comprehend the pathogenic mechanism of PV.