摘要
甘草对多种糖尿病模型动物具有降血糖的作用。甘草酸和甘草黄酮类化合物是其有效成分。甘草及其有效成分是⑴通过抗氧化作用,保护胰腺β-细胞,刺激胰岛素表达和分泌;⑵通过促进PPARs的表达和激活,抑制PTP1B的表达和活性和抑制11β-HSD1活性;通过抑制11β-HSD1活性,多方面地对抗胰岛素抵抗,促进组织细胞摄取和利用葡萄糖,改善脂、糖代谢紊乱;⑶通过抑制α-葡萄糖苷酶延缓肠道吸收葡萄糖,产生降糖作用。综述甘草及其有效成分降血糖的药理作用及其机制的文献资料,并对其研究进展作了分析。
Licorice has an effect of hypoglycemia to all sorts of diabetes model animals. Glycyrrhizic acid and licorice flavonoids are its active components. Licorice and its active components produce hypoglycemic effect：（1）by antioxidation, inducing protection of pancreatic β-cell, stimulating secretion and expression of insulin;（2）by improving activation and expression of PPARs, inhibiting activity and expression of PTP1 B, and inhibiting 11β-HSD1 activity, to antagonize insulin resistance to increase utilization and intake of glucose in tissue and cell, and to improve carbohydrate and lipid metabolic disorders;（3）by inhibiting activity of α-glucosidase to delay enteral absorption of glucose. In this paper, the literature data on pharmacologic effects and mechanisms of licorice and its active components in hypoglycemia and anti-diabetic complications are reviewed and the research advances are analyzed.
出处
《抗感染药学》
2015年第1期1-5,共5页
Anti-infection Pharmacy
