布拉酵母菌散联合蒙脱石散早期预防新生儿高胆红素血症的疗效

Effect of Saccharomyces boulardii Sachets combined with Montmorillonite Powder for primary prevention of hyperbilirubinemia in newborns

目的探讨布拉酵母菌散联合蒙脱石散早期预防新生儿高胆红素血症的疗效。方法选择正常足月新生儿86例,随机分为干预组和对照组各43例。两组新生儿均于生后进行纯母乳喂养。干预组在纯母乳喂养基础上加用布拉酵母菌散联合蒙脱石散口服,连用5 d。其中布拉酵母菌散0.125 g/次,1次/d,母乳喂养后口服;蒙脱石散剂1 g,3次/d,母乳喂养后口服。对照组不采取任何干预措施。观察并记录两组干预前后血清总胆红素水平的变化,并比较两组血清胆红素的峰值、黄疸持续时间、胎便排空时间及大便频率。结果干预5 d后,两组血清总胆红素水平均较干预前不同程度上升(P<0.05或P<0.01),干预组上升幅度明显低于对照组(P<0.05);同时干预组血清胆红素峰值、黄疸持续时间、胎便排空时间明显少于对照组(P<0.05),干预组的大便频率明显多于对照组(P<0.05)。结论口服布拉酵母菌散联合蒙脱石散早期预防新生儿高胆红素血症的疗效较显著,能降低体内血总胆红素水平,缩短黄疸持续时间,加快胎粪的排泄,对预防新生儿高胆红素血症的发生具有良好的作用。

Objective To discuss the effct of Saccharomyces boulardii Sachets combined with Montmorillonite Powder for primary prevention of hyperbilirubinemia of newborns. Methods 86 normal term newborns were selected and divided into intervention group and control group at random,with 43 cases in either group. Both groups were given exclusive breastfeeding after birth,while the intervention group was additionally given Saccharomyces boulardii Sachets combined with Montmorillonite Powder for 5 days（ 0. 125 g Saccharomyces boulardii Sachets q. d. and1 g Montmorillonite Powder t. i. d. orally after breastfeeding）. The changes of serum hyperbilirubinemia levels of newborns in both groups were observed and recorded,and peak of serum hyperbilirubinemia,duration of jaundice,time to meconium evacuation and stool frequency of newborns in the two groups were compared. Results The serum hyperbilirubinemia levels of newborns in both groups increased by different degrees after the intervention（ P 0. 05 or P 0. 01）,with the rising rate in intervention group much lower than that in control group（ P 0. 05）.The peak of serum hyperbilirubinemia,duration of jaundice and time to meconium evacuation were lower or shorter than those in control group（ P 0. 05）,while the stool frequency was much higher than that in control group（ P 0. 05）. Conclusion Oral Saccharomyces boulardii Sachets combined with Montmorillonite Powder has significant curative effect on hyperbilirubinemia of newborns,which can reduce serum hyperbilirubinemia level,shorten the duration of jaundice,speed up meconium evacuation and help to prevent the occurrence of hyperbilirubinemia in newborns.