系统性疾病治疗与口腔病灶感染

The treatment of systemic diseases and oral focal infection

口腔病灶被证实与许多系统性疾病的发生及发展有很大的相关关系,全身系统性疾病的治疗又会加重口腔病灶的感染,影响患者的生存质量,干扰系统性疾病的治疗,严重则造成全身感染。可能诱发或加重口腔病灶感染的系统性疾病治疗有:口服抗癫痫药物、免疫抑制剂等药物导致的药物性牙龈炎;恶性肿瘤放化疗并发的口腔黏膜炎;长期应用抑制肿瘤骨转移或预防骨质疏松的双磷酸盐造成的颌骨坏死;异基因造血干细胞移植后的口腔排异反应等。

Oral lesions were proved to have high correlation with the occurrence and development of many diseases. On the other hand,treatment of systemic diseases may aggravate oral focal infections,affect life quality of patients,interfere the treatment of systemic diseases and cause severe systemic infection. These treatments of systemic diseases which may induce or aggravate oral local lesion infections include： some oral anti-epileptic drugs and immunosuppressive drugs that may induce gingivitis,radiotherapy or chemotherapy that can intrigue oral mucositis due to immune function damage,long-term use of bisphosphonates for inhibition of malignant tumor bone metastasis or prevention of osteoporosis that will cause osteonecrosis of the jaw,as well as allogeneic hematopoietic stem cell transplantation that may cause oral rejection reactions,etc.