血清降钙素原对ICU脓毒症患者的临床意义

Clinical Significance of Procalcitonin for Sepsis in ICU

目的探讨血清降钙素原（procalcitonm，PCT）对重症监护病房（ICU）脓毒症患者早期病情评估及预后的临床意义.方法回顾性分析2013年1月～2014年1月沈阳市第四人民医院ICU收治的68例脓毒症患者，其中脓毒症组30例，严重脓毒症组38例．分析比较脓毒症和严重脓毒症患者入ICU时的血清白细胞计数（white blood cell count，WBC）、C反应蛋白（c—rcactive protein，CRP）及降钙素原（PCT）水平、急性生理与慢性健康状况评分Ⅱ（APACHEⅡ评分）。结果严重脓毒症组血清WBC、CRP、PCT及APACHEⅡ评分均高于脓毒症组，两组这间存在统计学差异（均P〈0.05）。结论血清PCT对脓毒症早期诊断、监测病情有重要的临床价值。

Objective To investigate the clinical significance of procalcitonin （ PCT ） in early diagnonsis of sepsis and evaluation of prognosis in ICU. Methods P, etrospective analysis of 68 patients from January 2013 to January 2014 was performed in ICU of Shenyang The forth hospital of people including the sepsis group（ 30 cases ）and the sever sepsis group（ 38 cases ）. The data collected included blood white blood cell count（ WBC ）, c-reactive protein（ CRP ）, procalcitonin （ PCT ） and acute physiology and chronic health evaluation Ⅱ （ APACHE Ⅱ ） on the day of hospitalization in ICU. Results The level ofWBC, CRP, PCT and APACHE II score of the sever sepsis group were significantly higher than those in sepsis group, and the differences showed statistically significance （ P〈0.05 ） . Conclusion PCT indicated important clinical value for early diagnosis of sepsis and assessment of disease condition.