期刊文献+

二甲双胍在妊娠糖尿病治疗中的应用分析 被引量:5

The Application Analysis of Melbine(DMBG) in Treatment of Gestational Diabetes
下载PDF
导出
摘要 目的分析妊娠糖尿痛应用二甲双胍治疗的临床效果。方法选取2013年2月~2014牟8月间我院收治的妊娠糖尿病患者81例,分为两组。对照组应用胰岛素注射治疗,观察组同时应用二甲双胍口服治疗,对比两组血糖控制效果与妊娠结局。结果两组血糖控制效果无显著差异(P〉0.05),但观察组妊娠期间并发症发生率(6.81%)与对照组(35.13%)比较相对较低,妊娠结局良好,两组治疗效果差异有统计学意义(P〈0.05),结论妊娠糖尿病应用二甲双胍治疗能够改善妊娠结局,控制血糖,安全可靠. Objective The clinical efficacy ofMelbine (DMBG) in treatment of gestational diabetes is to be discussed. Methods Choose 81 gestational diabetes patients who are treated in hospital from February 2013 to August 2014 and separate them into two groups. Patients in control group are given insulin injection treatment, while patients m study group are given Melbine ( DMBG ) treatment, and then observe and compare the blood-sugar control effect and pregnancy outcomes of these two groups. Results There is no ditgerential between the two groups with regarding to blood-sugar control effect ( P〉0.05 ), however, the gestational complication incidence of patients in study group ( 6.81% ) is much less than control group ( 35.13% ), the patients in study group achieve much more favorable pregnancy outcomes, and such a differential has statistic value ( P〈0.05 ) . Conclusion Melbine ( DMBG ) is of efficiency in treatment of gestational diabetes and it is conducive to contrulling blood-sugar with safety; thus, such a treatment approach is quite worthwhile to he promoted and applied.
作者 闫亚杰
出处 《中国卫生标准管理》 2015年第5期225-227,共3页 China Health Standard Management
关键词 二甲双胍 妊娠糖尿病 临床治疗 Melbine ( DMBG ), Gestational diabetes, Clinical treatment
  • 相关文献

参考文献3

二级参考文献35

  • 1孙芳,姚凤媚,温芳莉.二甲双胍联合达英35促进多囊卵巢综合征排卵的效果[J].广东医学,2007,28(5):808-810. 被引量:16
  • 2Shashank R Joshi. Metfonnin:Old wine in new bottle - evolving technology and therapy in diabetes[J]. JAPI,2005,53:963-972.
  • 3Bailey CJ,Turner RC. Metformin[J]. N Engl J Meal,1996,334: 574- 579.
  • 4Cusi K, DeFronzo RA. Metformin : a review of its Metabolic effects [ J]. Diabetes Review, 1998,6:89- 131.
  • 5Wiernsperger NF, Bailey CJ. The antihyperglycaemic effect of Metformin : therapeutic and cellular mechanisms [J ]. Drugs, 1999,58 : 31-39.
  • 6Gunton JE, Delhanty PJ, Takahashi S, et al. Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin - receptor substrate - 2[ J]. J Clin Endocrinol Metab,2003,88 : 1323- 1332.
  • 7Witters LA. The blooming of the French lilac [J ]. J Clin. Invest. 2001,108:1105- 1107.
  • 8Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes:A consensus algorithm for the initiation and adjustment of therapy a consensus statement of the american diabetes association and the european association for the study of diabetes[ J ]Diabetes Care ,2009,32:193- 203.
  • 9UK Prospective Diabetes Study (UKPDS) Group: Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complication in patients with type 2 diabetes ( UKPDS 33). Lancet,1998,352:837- 853.
  • 10Giacchi M, Vatti R. Inhibitory effect of Metformin on the development of cholesterol atherosclerosis in the rabbit. Observations on the coronary vessels[ J]. Boll Soc hal Biol Sper, 1981,57:552-555.

共引文献37

同被引文献34

  • 1王蕴慧,李玲,梁立阳,等.口服二甲双胍对妊娠期糖尿病患者妊娠结局及新生儿的影响[J].中华临床医师杂志(电子版),2013(11):4830-4834.
  • 2Gui J,Li A,Su X,et al.Association between hyperglycemia in mid dle and late pregnancy and maternal-fetal outcomes:aretrospectiv study[J].BMC Pregnancy Childbirth,2014,14(1):34-40.
  • 3Hiersch L,Yogev Y.Impact of gestational hyperglycemia on ma ternal and child health[J].Curr Opin Clin Nutr Metab Care2014,17(3):255-260.
  • 4Hewapathirana NM,Murphy HR.Perinatal outcomes in type 2 dia betes[J].Curr Diab Rep,2014,14(2):461-467.
  • 5Koren G.GIyburide and fetal safety;transplacental pharmacokineti considerations[J].Reprod Toxicol,2001,15:227-229.
  • 6S hepard TH.Catalog of teratogenic agents[M].8thed.Baltimore(MO):Johns Hopkins Universitv Press,2004.247-248.
  • 7Kraemer J,Klein J,Lubelsky A,el a1.Perfusion studies of giy buride transfer across the human placenta:implications for feta safety[J].Am J Obstet Gynecol,2006,195:270-274.
  • 8Langer O,Yogev Y,Xenakis EM,et a1.Insulin and glyburid therapy:dosage,severity level of gestational diabetes,and pregnan cy outcome[J].Am J Ohstel Gynecol,2005,192:134-139.
  • 9Steel JM,J0hnstone FD.Sulphonylureas in pregnancv[J].Lancet1991,338:1222.
  • 10Hoh RI,Clarke P,Parry Ec,el a1.The effectiveness of glibenelamid in women with gcstational diabetes[J].Diabetes Obes Melab2008,10:906-911.

引证文献5

二级引证文献19

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部