甲氨蝶呤与米非司酮联合用于输卵管妊娠治疗的临床探析

Explore the Effect of Methotrexate Combination With Mifepristone in the treatment of Oviducal Pregnancy

目的：探讨甲氨蝶呤与米非司酮联合用于输卵管妊娠治疗的临床效果。方法选取2013年10月～2014年10月我院接诊的68例输卵管妊娠患者，按照入院的先后顺序分为两组，实验组和对照组，对照组采用单纯甲氨蝶呤治疗，实验组采用甲氨蝶呤与米非司酮联合治疗，观察两组患者的治疗效果。结果实验组患者的治疗总有效率明显高于对照组，差异显著，有统计学意义（P〈0.05）；实验组患者血清绒毛膜促性腺激素（HCG）、盆腔包块直径、不良反应的发生率明显低于对照组，差异显著，有统计学意义（P〈0.05）。结论甲氨蝶呤与米非司酮联合用于输卵管妊娠治疗的效果显著，降低血清绒毛膜促性腺激素（HCG）水平，缩小盆腔包块直径，减少不良反应的发生率，值得临床广。

Objective To explore the effect of Methotrexate combination with Mifepristone in the treatment of oviducal pregnancy.Methods68 oviducal pregnancy patients who were treated in our hospital from October 2013 to October 2014 were selected. They were divided into study group and control group according to their hospitalization sequence. The patients in control group were given Methotrexate only,while the patients in study group were given methotrexate and mifepristone. We observed and compared the treatment effects of the two groups.Results The treatment effects in study group was much better than control group,with a statistical significant difference（P〈0.05）. Besides,the value of serum human chorionic gonadotropin（HCG）,the pelvic diameter and side-effect incidence in study group were lower than counterparts in control group,with a statistical significant difference（P〈0.05）.Conclusion Methotrexate combination with mifepristone is effect in the treatment of oviducal pregnancy. This method is conducive to decreasing HCG,and reducing pelvic diameter and side-effect incidence. Thus, such a treatment approach is quite worthwhile to be promoted and applied.