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Infective Endocarditis-induced Crescentic Glomerulonephritis Dramatically Improved after Removal of Vegetations and Valve Replacement 被引量:4

Infective Endocarditis-induced Crescentic Glomerulonephritis Dramatically Improved after Removal of Vegetations and Valve Replacement
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摘要 Infective endocarditis (IE) is associated with poor prognosis and higher mortality. IE-induced glomerulonephritis, especially crescentic glomerulonephritis (IE-CGN) with renal dysfunction, is an independent risk factor for mortality For the treatment of IE-CGN, many therapeutic strategies including antibiotics alone, antibiotics combined with corticosteroid, immunosuppressive agents, plasmapheresis, or cardiac surgery have been applied and obtained various results.C21 Here, we reported a case of CGN with progressive renal failure secondary to IE in which the renal function was dramatically improved by the treatment of surgical valve replacement and antibiotics. Infective endocarditis (IE) is associated with poor prognosis and higher mortality. IE-induced glomerulonephritis, especially crescentic glomerulonephritis (IE-CGN) with renal dysfunction, is an independent risk factor for mortality For the treatment of IE-CGN, many therapeutic strategies including antibiotics alone, antibiotics combined with corticosteroid, immunosuppressive agents, plasmapheresis, or cardiac surgery have been applied and obtained various results.C21 Here, we reported a case of CGN with progressive renal failure secondary to IE in which the renal function was dramatically improved by the treatment of surgical valve replacement and antibiotics.
机构地区 Division of Nephrology
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第3期404-406,共3页 中华医学杂志(英文版)
关键词 Infective Endocarditis Crescentic Glomerulonephritis Heart Valve Replacement Surgery Infective Endocarditis Crescentic Glomerulonephritis Heart Valve Replacement Surgery
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参考文献6

  • 1Buchholtz K, Larsen CT, Hassager C, Bruun NE. In infectious endocarditis patients mortality is highly related to kidney function at time of diagnosis: a prospective observational cohort study of 231 cases. Eur J Intern Med 2009,20:407-10.
  • 2Kannan S, Mattoo TK. Diffuse crescentic glomerulonephritis in bacterial endocarditis. Pediatr Nephrol 2001 , 16:423-8.
  • 3Naber CK, Erbel R. Infective endocarditis with negative blood cultures, lnt J Antimicrob Agents 2007,30 Suppl 1 :$32-6.
  • 4Gould FK, Denning DW, Elliott TS, Foweraker J, Perry JD, Prendergast BD, et aL Guidelines for the diagnosis and antibiotictreatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother 2012,67:269-89.
  • 5Manzoor K, Khan S, Ahmed E, Akhter F, Mubarak M, Naqvi SA, et al. Crescentic glomerulonephritis associated with bacterial endocarditis - Antibiotics alone may be sufficient. A case report. J Pak Med Assoc 2005,55:352-4.
  • 6Gao GW, Lin SH, Lin YF, Diang LK, Lu KC, Yu FC, et al. Infective endocarditis complicated with rapidly progressive glomerulonephritis: a case report. JCMA 1996,57:438-42.

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