中国人载脂蛋白E基因多态性与轻度认知功能损害关系的Meta分析

Relationship between apolipoprotein E gene polymorphism and mild cognitive impairment in Chinese population: a Meta analysis

目的：探讨中国人载脂蛋白E基因多态性与轻度认知功能损害（ mild cognitive impairment, MCI）的相关性。方法：检索已发表的中国人载脂蛋白E基因多态性与轻度认知功能损害的相关病例对照研究,选择符合条件的文献进行Meta分析。采用RevMan 5.2统计软件进行数据处理。采用漏斗图评价入选文献的发表偏倚。结果：共入选9篇符合条件的文献纳入Meta分析。分析结果显示,携带ε2/2、ε3/3、ε4/4、ε2/3、ε2/3、ε3/4的个体发生轻度认知功能损害的 OR 值为0.97（95%CI 0.31~3.02）、0.43（95%CI 0.34~0.55）、2.68（95%CI 1.42~5.06）、0.67（95%CI 0.47~0.96）、2.51（95%CI 1.61~3.91）、2.40（95%CI 1.80~3.21）。携带ε4、ε3、ε2的个体OR值为2.68（95%CI 2.14~3.35）、0.46（95%CI 0.38~0.56）、1.12（95%CI 0.87~1.44）。结论：ε4是轻度认知功能损害的遗传易感基因,ε3可能是保护基因。同时, ApoEε4/4、ApoEε2/4和ApoEε3/4基因型是MCI的危险因素,ApoEε3/3与ApoEε2/3基因型是MCI的保护因素。

Objective：To study the relationship between apolipoproteion E gene polymorphism and mild cognitive impairment（ MCI） in Chinese population. Methods： The literatures with ApoE polymorphism and mild cognitive impairment concerning Chinese population were reviewed. The selected literatures were analyzed by Meta analysis. The software RevMan 5. 2 was used for Meta analysis and publication bias was tested by funnel plot. Results：Nine papers were selected based on the criteria. Meta analysis results showed that the combined OR values of mild cognitive impairment for subjects of ε2/2 ,ε3/3 ,ε4/4 ,ε2/3 ,ε2/3 ,ε3/4 were 0 . 97 （ 95%CI 0 . 31 -3 . 02 ） ,0 . 43 （95%CI 0. 34-0. 55）,2. 68（95%CI 1. 42-5. 06）,0. 67（95%CI 0. 47-0. 96）,2. 51（95%CI 1. 61-3. 91）, 2. 40（95%CI 1. 80 -3. 21）,respectively. The pooled OR values of mild cognitive impairment forε4,ε3 andε2 carriers were 2 . 68 （ 95% CI 2 . 14 -3 . 35 ） , 0 . 46 （ 95% CI 0 . 38 -0 . 56 ） , 1 . 12 （ 95% CI 0 . 87 -1 . 44 ） , respectively. Conclusions：The ApoEε4 carriers might be a risk factor andε3 carrers be a protective factor for mild＆nbsp;cognitive impairment. Meanwhile ApoE ε4/4, ApoE ε2/4 and ApoE ε3/4 genotypes increase and ApoE ε3/3, ApoE ε2/3 genotype decrease the risk of MCI.