高血压患者角膜内皮细胞形态学的研究分析

Morphological study of corneal endothelial cells in patients with hypertension

目的:探讨原发性高血压病对角膜内皮的影响。方法:应用全自动角膜内皮细胞分析仪对296例348眼进行角膜厚度及内皮细胞形态检测。原发性高血压患者148例173眼,其中A组(Ⅰ、Ⅱ期)87例104眼,B组(Ⅲ、Ⅳ期)61例69眼;正常对照组148例175眼。各组之间年龄、性别差异无统计学意义,且均排除其他全身疾病史。对各组角膜内皮细胞的平均密度、六边形细胞比例、变异系数及中央角膜厚度进行统计学分析。结果:高血压组患者较正常对照组角膜内皮细胞变异系数和中央角膜厚度增加,六边形细胞比例以及中央角膜内皮细胞密度减少,差异具有统计学意义(P<0.05或P<0.01);高血压B组与高血压A组相比较4项指标之间差异均有统计学意义(P<0.05或P<0.01)。结论:原发性高血压患者角膜内皮细胞形态结构存在异常,且随病变程度的加重而加重。对合并患有高血压的患者在进行内眼手术时应特别注意保护角膜内皮,防止角膜内皮功能失代偿。

Objective： To investigate the effect of hypertension on corneal endothelial cells. Methods： The automatic corneal endothelial cells analytical application were used to detect the corneal thickness and endothelial cell morphology with 296 cases （348 eyes） . Patients with stages I and II hypertension were enrolled in the Group A while those with stages III and IV hypertension in the Group B. Of a total of 148 patients with hypertension （173 eyes） , 87 cases（104 eyes） were enrolled in the Group A while 61 cases（69 eyes） in the Group B. Among all the subjects, there were no statistical differences in gender, age, and the exclusion of other systemic disease history. Statistical analysis was made on the corneal endothelial cells into the average density, percentage of hexagonal cells, coefficient of variation and central corneal thickness. Results： Compared with normal controls, both coefficient of variation and central corneal thickness increased while percentage of hexagonal cells and central corneal endothelial cell densities decreased in patients with hypertension, with a significant difference （P〈0. 05 or P〈0. 01）. Meanwhile, for hypertension, there were significant differences in four indicators between Groups A and B （ P〈0 . 05 or P〈0 . 01 ） . Conclusion：There are abnormal morphology of corneal endothelial cells in primary hypertension patients, which are aggravated with the severity of disease. So when the ophthalmologist conduct the＆nbsp;intraocular operation with hypertension patients, they should pay special attention to the protection of the cornea endothelial to prevent corneal endothelial decompensation.