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CD4-CD8-双阴性T细胞在B细胞介导免疫反应中的作用 被引量：10

Function and roles of CD4-CD8-double negative T cells in the immune response mediated by B cells
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摘要 最近研究表明调节T细胞在免疫反应中发挥重要作用。CD4-CD8-双阴性T细胞(double negative T cell,DNT细胞),1种较少的调节T细胞亚群,在移植、肿瘤及自身免疫过程中发挥抗原特异性免疫调节功能。目前,在人类及小鼠的研究中发现DNT细胞不仅能抑制细胞和体液免疫应答,而且可以输入体内作为一种体细胞治疗来实现诱导免疫耐受和预防疾病。在这篇综述中,我们主要关注DNT细胞的起源,分子表型及其在B细胞相关免疫反应中的作用机制,以期利用DNT细胞更好地治疗B细胞介导的免疫性疾病。 Recent research has indicated that regulator T cells play significant role in immune responses.CD4-CD8-double negative T cells（DNT cells）,a rare regulatory T cell subset,play immune regulatory function in transplantation,tumor and autoimmune diseases. At present,many studies of human and mouse have showed that DNT cells not only restrict cell and humoral immune response,but also induce immune tolerance and be used for prevention of diseases as a cell therapy. In this review,we concentrate on the origin,molecular phenotype,and the mechanism of CD4-CD8-double negative T cells in the immune response mediated by B cells,which may benefit the treatment of immune diseases mediated by B cells.
作者 李稳霞 张栋 李照 高鹏骥 高杰 朱继业
机构地区 北京大学人民医院肝胆外科 首都医科大学附属北京友谊医院实验中心
出处 《免疫学杂志》 CAS CSCD 北大核心 2015年第2期171-175,共5页 Immunological Journal
关键词 双阴性T细胞 B细胞 移植 自身免疫 Double negative T cells B cells Transplantation Autoimmune diseases
分类号 R392.4 [医药卫生—免疫学]
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共引文献25

同被引文献76

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免疫学杂志
2015年 第2期

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