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β-羟基异戊酰紫草素对子宫颈癌裸鼠移植瘤生长的影响及机制研究

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摘要 子宫颈癌是全球高发的妇科恶性肿瘤,严重威胁妇女健康,研究子宫颈癌演变的分子机制以及治疗方案已经刻不容缓,而HPV感染是子宫颈癌最主要的危险因素[1].近年来,磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（Akt）/雷帕霉素靶蛋白（mTOR）被认为是蛋白质合成的重要信号通路,参与调节细胞增殖、分化、迁移等[2].有研究发现,HPV可经PI3K/Akt通路促进恶性肿瘤进展[3].
作者 卢丹 钱静 冯倩倩 潘枢 张思泉
机构地区 扬州大学临床医学院妇产科
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2015年第1期56-59,共4页 Chinese Journal of Obstetrics and Gynecology
基金 江苏省社会发展科技计划（BS2006536） 江苏省普通高校研究生科研创新计划（CXZZ13_0918）
关键词 子宫颈癌 移植瘤生长 PI3K/AKT通路 紫草素 磷脂酰肌醇3激酶 妇科恶性肿瘤 雷帕霉素靶蛋白 HPV感染
分类号 R285.5 [医药卫生—中药学]
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参考文献10

  • 1魏丽惠.子宫颈癌防治任重道远[J].中华妇产科杂志,2013,48(4):304-306. 被引量：9
  • 2Xu Y, Li N, Xiang R, et al. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oneogene-indueed senescence[J]. Trends Biochem Sci,2014,39 (6) :268-276.
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二级参考文献11

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中华妇产科杂志
2015年 第1期

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