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嵌合抗原受体——癌症免疫治疗的新希望 被引量：7

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摘要 随着医学免疫学与分子生物学的发展,癌症治疗不再局限于传统的药物与手术疗法.从最初的肿瘤疫苗到现在举世瞩目的嵌合抗原受体（chimeric antigen receptor,CAR）修饰T细胞,癌症的免疫治疗正逐步走向于临床舞台并造福于癌症患者.CAR的概念源于人们对癌症免疫治疗的进一步认识：即免疫细胞可以突破MHC的限制直接识别并杀伤癌细胞.1989年Gross等[1]首次提出CAR的概念,将针对肿瘤细胞抗原单克隆抗体的可变区和T细胞受体（T cellreceptor,TCR）融为一体,重新定向T细胞的免疫反应.随着转化医学的发展,CAR的研究正在吸引着更多人的关注,并且在临床试验治疗白血病、淋巴瘤等恶性血液肿瘤方面取得了重大突破[2-3].本文将对CAR-T细胞的构成及发展、研究现状、面临的挑战及应用前景等作一综述.
作者 鹿萍 郝莎 袁卫平 程涛
机构地区 中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室
出处 《中华医学杂志》 CAS CSCD 北大核心 2015年第4期311-314,共4页 National Medical Journal of China
基金 国家重点基础研究发展计划（973计划）（201ICB964801） 国家科技重大专项（2011ZX09102-010-04） 天津市应用基础与前沿技术研究计划（11JCZDJC27900、13JCYBJC39400）
关键词 癌症患者 免疫治疗 抗原受体 嵌合 T细胞受体 receptor 恶性血液肿瘤 肿瘤疫苗
分类号 R730.51 [医药卫生—肿瘤]
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参考文献37

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二级参考文献94

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共引文献21

同被引文献143

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中华医学杂志
2015年 第4期

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