原发性高血压患者踝臂动脉脉搏波传导速度与中心动脉压及颈动脉内膜厚度的相关性

Relationship between brachial ankle pulse wave velocity,central arterial pressure and intima-media thickness in patients with essential hypertension

目的:探讨原发性高血压患者踝臂动脉脉搏波传导速度(baPWV)与颈动脉内膜中层厚度(IMT)及中心动脉压(CAP)的关系。方法:收集原发性高血压患者共444例,对所有患者进行IMT、baPWV及CAP的测定。根据baPWV分为异常组(baPWV≥14m/s,208例)和正常组(baPWV<14m/s,236例)。用简单相关分析检测baPWV与CAP及IMT的相关性。采用Logistic回归分析baPWV与CAP及IMT的关系。结果:Pearson相关分析显示,baPWV与年龄、24h平均收缩压(24hSBP)、白昼平均收缩压(dSBP)、夜间平均收缩压(nSBP)、中心动脉收缩压(CASP)、中心动脉舒张压(CADP)、中心动脉脉压(CAPP)、反射波压力(AP)、中心动脉压增强指数(AIx)、75次心率AIx校正指数(AIx75)及IMT相关(P<0.05)。进一步控制年龄、24hSBP、dSBP、nSBP后,CASP、CADP、CAPP、AP、AIx75、IMT仍与baPWV相关。Logistic回归分析显示,CASP、CAPP、IMT与baPWV相关。结论:CASP、CAPP、IMT是baPWV增加的危险因素。

Objective ： To investigate the relationship between brachial ankle pulse wave velocity （baPWV）, intima-media thickness （IMT）and central arterial pressure （CAP） in patients with essential hypertension. Method： Four hundred and forty-four cases of essential hypertensive patients were included. The clinical data of patients were determined, including IMT, baPWV and CAP. The patients were subdivided into 2 groups based on baPWV results： 236 patients in normal group （baPWV〈14 m/s）, and 208 patients in abnormal group （baPWV≥14 m/ s）. The relationship between baPWV, IMT and CAP was evaluated with Spearman rank correlation analysis. And the relationship between baPWV, IMT and CAP was examined with Logistic regression analysis. Result：Pearson correlation analysis showed that baPWV was related with age, 24hSBP, dSBP, nSBP, CASP, CADP, CAPP, AP, AIx, AIx75, IMT（all P〈0. 05）. Further adjustment for age, 24bSBP, dSBP and nSBP,CASP, CADP, CAPP, AP, AIx75, IMT were still associated with baPWV. Binary Logistic regression analysis showed that CASP, CAPP and IMT were related with baPWV. Conclusion： CASP, CAPP and IMT are the main risk factors for baPWV.