降钙素原、超敏C反应蛋白、D-二聚体和纤维蛋白原在COPD急性加重期患者的动态变化及临床意义

The value of procalcitonin,high-sensitivity c-reactive protein,D-dimer,fibrinogen in acute exacerbation of chronic obstructive pulmonary disease patients

目的探讨降钙素原(PCT)、超敏C-反应蛋白(Hs-CRP)、D-二聚体、纤维蛋白原(FIB)在慢性阻塞性肺疾病急性加重期(AECOPD)中的动态变化,以及上述指标的临床意义。方法收集62例AECOPD患者入院时、入院治疗1周后、出院前的PCT、Hs-CRP、D-二聚体、FIB水平,并收集60例COPD稳定期患者的上述指标作为对照。结果 AECOPD组患者的入院时PCT、Hs-CRP、D-二聚体、FIB水平均高于对照组,差异有统计学意义(P<0.05);AECOPD患者治疗1周后,PCT、Hs-CRP、D-Dimer、FIB的水平显著下降;至出院前,上述指标均降至最低水平(P<0.05)。结论动态监测AECOPD患者的PCT、Hs-CRP、D-二聚体、FIB的变化,对患者病情的控制、治疗效果的监测、疾病的预后等有重要的意义。

Objective To investigate the dynamic changes and clinical significance of these indicators,Procalcitonin（ PCT）,high- sensitivity c- reactive protein（ HS- CRP）,d- dimer and Fibrinogen in acute exacerbation of chronic obstructive pulmonary disease（ AECOPD） patients. Methods The Hs- CRP,d- dimer,Fibrinogen level of 62 cases of chronic obstructive pulmonary disease patients were detected on admission,admission after 1 week of treatment,the PCT before discharge. At the same time,these indicators of 60 normal persons were detected and included as control group. Results AECOPD patients on admission and the admission after 1 week of treatment,discharge,a former PCT Hs-CRP,d- dimer,Fibrinogen levels were higher than those in the control group. AECOPD patients after 1 week,the PCT,Hs- CRP,D- Dimer,FIB levels decreased significantly. Before discharge,the above indexes have fallen to the lowest level（ P 0. 05）. Conclusion AECOPD dynamic monitoring in patients with PCT,Hs- CRP,d- dimer,Fibrinogen changes in control of the patient,the monitoring of treatment,the prognosis of the disease,which are of great significance.