功能性消化不良患者血清白介素-6浓度与焦虑抑郁评分的相关性研究

Correlation of serum IL-6 level with anxiety and depression scores in patients with functional dyspepsia

目的探讨血清白介素-6浓度与焦虑抑郁评分在功能性消化不良患者中的相关性。方法选取功能性消化不良患者63例和同期健康体检者60例为研究对象。采用化学发光法检测空腹血清白介素-6水平,以焦虑自测量表(SAS)和抑郁自测量表(SDS)对两组人群进行焦虑、抑郁评分。结果功能性消化不良患者血清白介素-6平均水平为(92.61±5.19)pg/ml,显著高于健康组的(63.95±4.65)pg/ml,差异有统计学意义(P<0.05);功能性消化不良患者SAS和SDS评分均显著高于健康组,差异有统计学意义(P<0.05);血清白介素-6浓度与SAS和SDS评分均呈正相关(r=0.68,P<0.05;r=0.63,P<0.05)。结论功能性消化不良患者白介素-6水平显著高于正常健康受试者,且与焦虑、抑郁评分呈正相关。

Objective To investigate the relationship between IL- 6 level and anxiety and depression scores in patients with functional dyspepsia. Methods Sixty- three functional dyspepsia patients and 60 healthy subjects were studied. Serum IL- 6 was detected using chemiluminescence method. Anxiety and depression scores were obtained by self- rating anxiety scale（ SAS） and self- rating depression scale（ SDS）.Results The average serum IL- 6 levels（ 92. 61 ± 5. 19 pg / ml） in functional dyspepsia patients were significantly higher than the healthy group（ 63. 95 ± 4. 65 pg/ml）（ P 0. 05）. SAS and SDS scores in functional dyspepsia patients were also significantly higher than the healthy group（P 0. 05）. Serum IL- 6 level was positively correlated SAS and SDS scores（ r = 0. 68,P 0. 05 and r = 0 63,P 0. 05,respectively）. Conclusion IL- 6 level was significantly higher in patients with functional dyspepsia than healthy subjects. IL- 6 level was positively correlated with anxiety and depression scores.