高强度聚焦超声联合化疗治疗结直肠癌肝转移临床研究

Clinical study on effect of highly intensified focused ultrasound combined chemotherapy in treatment of liver metastasis of colorectal cancer

目的对比观察高强度聚焦超声联合化疗与单纯化疗治疗结直肠癌肝转移临床疗效。方法 80例结直肠癌肝转移随机分为研究组(高强度聚焦超声联合化疗)40例和对照组(单纯化疗)40例。观察两组临床疗效、KPS评分、疼痛评分、肝功能变化、生存率及不良反应。结果研究组有效率为70.0%(28/40)明显高于对照组47.5%(19/40),但两组疾病控制率无显著差异;治疗前、后两组间KPS评分无显著差异;两组疼痛评分均有较明显减轻,但研究组较对照组疼痛减轻更明显;治疗前后两组间肝功能变化无显著差异;研究组1年生存率达到82.5%,明显高于对照组60.0%(P<0.05);但2年生存率两组无显著差异;两组的不良反应无显著差异。结论高强度聚焦超声联合化疗治疗结直肠癌肝转移疗效好,疼痛减轻更明显,1年生存率较高。

Objective To compare the clinical efficacy of highly intensified focused ultrasound combined chemotherapy and simple chemotherapy in treatment of patients with liver metastasis of colorectal cancer.Methods Eighty patients with liver metastasis of colorectal cancer were divided into study group（ with treatment of high intensified focused ultrasound combined with chemotherapy） for 40 cases and control group（ only chemotherapy） for 40 cases.Their curative effect,KPS scores,pain scores,changes in hepatic function,survival rate and adverse reactions were compared between these 2 groups.Results The effective rate of study group was 70.0%（ 28 /40）,it was obviously higher than that [47.5%（ 19 /40） ]of control group,but the rate of disease control had no obvious difference.The difference in KPS scores between these two groups before and after treatment was not significant.The pain scores of two groups were significantly reduced after treatment,but it was better in study group than control group.The difference in change of liver function in these 2 groups before and after treatment was not significant.One year＇s survival rate in study group was 82.5%,and it in control group was only 60.0%（ P0.05）.But the data of 2 years survival rate showed no obvious difference.There was no obvious difference in adverse reactions between these two groups.Conclusion The efficacy of therapeutic regimen with highly intensified focused ultrasound combined chemotherapy in treatment of patients with colorectal cancer having liver metastasis is good,it will remit the pain and its one year survival rate is higher.