某院革兰阴性杆菌对美罗培南与亚胺培南体外敏感性比较

Comparative antimicrobial activity of Meropenem and Imipenem against Gram-negative bacilli in vitroin our hospital

目的:比较美罗培南和亚胺培南对687株临床分离的革兰阴性杆菌体外抗菌活性,为抗感染治疗的药物选择提供参考。方法:采用MIC法测定同一株革兰阴性菌对亚胺培南和美罗培南的敏感性,对细菌的耐药结果进行统计学分析。结果:150株大肠埃希菌、245株肺炎克雷伯菌和137株鲍曼不动杆菌对亚胺培南、美罗培南的敏感菌株之比是146∶147、233∶232和24∶22,经χ2检验P>0.05,两药敏感性差异无统计学意义;但铜绿假单胞菌对美罗培南的敏感率高于亚胺培南(P<0.05),鲍曼不动杆菌对亚胺培南、美罗培南的敏感率均小于20%。结论:亚胺培南和美罗培南对肠杆菌科仍保持高活性有同样有效,对于铜绿假单胞菌引起的严重感染,美罗培南体外试验有着较高抗菌活性。亚胺培南和美罗培南对鲍氏不动杆菌疗效不佳。

OBJECTIVE To compare antimicrobial activity of meropenem（MRP）and imipenem（IMP）against 687 Gramnegative bacilli isolated from patients in our hospital,provide references of drug selection.METHODS The sensitivity of MRP and IMP to the same Gram-negative bacilli strain was detected by MIC method,their drug resistances were compared and statistically analyzed.RESULTS The sensitive rates of 150 Escherichia coli,245 Klebsiella pneumonia and 137 Acinetobacter baumannii to MRP and IMP were 146∶147,233∶232 and 24∶22,andχ^2 test results showed that the two groups had no significant difference（P〉0.05）.The sensitivity of MRP to Pseudomonas aeruginosa was higher than IMP（P〉0.05）.The sensitive rates of Acinetobacter baumannii to MRP and IMP were lower than 20%.CONCLUSION Imipenem and meropenem are both potent against Escherichia coli and Klebsiella pneumonia,and MRP has higher antimicrobial activity against Pseudomonas aeruginosa than IMP.MRP and IMP show poor effects against Acinetobacter baumannii in vitro.