藏药革叶兔耳草化学成分的研究

Study on the chemical constituents of Lagotis alutacea

对产于云南香格里拉的革叶兔耳草(Lagotis alutacea W.W.Smith)的化学成分进行研究.用硅胶柱层析对化合物进行分离,并用光谱方法进行结构鉴定.共分离鉴定了11个化合物:10-O-(3,4-dimethoxy-(E)-cinnamoyl)catalpol(1),10-O-(3,4-dimethoxy-(Z)-cinnamoyl)catalpol(2),ehrenoside(3),lagotoside(4),木犀草素(luteolin,5),木犀草素-4'-甲醚(luteolin-4'-methyl ether,6),木犀草素-7-O-β-D-葡萄糖苷(luteolin-7-O-β-D-glucoside,7),茴香酸(anisic acid,8),香草醛(vanillin,9),β-谷甾醇(β-sitosterol,10)和胡萝卜苷(daucosterol,11).以上化合物均为首次从该植物中分离得到.

The chemical constituents of Lagotis alutacea W. W. Smith collected in Shangri La were studied.The compounds were isolated by silica column chromatography,and the structures were elucidated by spectral methods.Eleven compounds were isolated and identified as 10-O-（ 3,4-dimethoxy-（ E）-cinnamoyl） catalpol（ 1）,10-O-（ 3,4-dimethoxy-（ Z）-cinnamoyl） catalpol（ 2）,ehrenoside（ 3）,lagotoside（ 4）,luteolin（ 5）,luteolin-4＇-methyl ether（ 6）,luteolin-7-O-β-D-glucoside（ 7）,anisic acid（ 8）,vanillin（ 9）,β-sitosterol（ 10） and daucosterol（ 11） respectively.All the compounds were isolated from this plant for the first time.