Ⅰ型心肾综合征伴利尿剂抵抗患者炎性细胞因子的变化

The Changes in Inflammatory Cytokines of Cardiorenal Syndrome Type 1 Patients with Diuretic Resistance

目的：探讨炎症反应在Ⅰ型心肾综合征患者并发利尿剂抵抗中的影响.方法：收集2012年8月～ 2014年8月温州市人民医院收治的Ⅰ型心肾综合征患者,根据是否发生利尿剂抵抗,分为心肾综合征组和利尿剂抵抗组,统一检测两组患者血清TNF-α、IL-1β、IL-6、CRP等炎症因子水平,同时同正常健康人群进行对比,了解3组人群血清中炎性细胞因子的不同.结果：58例Ⅰ型心肾综合征患者,分为心肾综合征组（30例）和利尿剂抵抗组（28例）,同时随机抽选健康体检人群（27例）,统计分析显示3组间患者炎性细胞因子比较差异有统计学意义（P＜0.05）.结论：炎症反应不仅参与了Ⅰ型心肾综合征患者的病理生理过程,而且在其严重并发症利尿剂抵抗的发生发展过程中也发挥了重要作用.

Objective：To explore the impact of inflammation in the event of diuretic resistance in patients with type I car- diorenal syndrome. Methods：From August 2012 to August 2014 ,the patients with type I eardiorenal syndrome in Wenzhou People＇s Hospital were analyzed. Depending on the occurrence of diuretic resistance, the patients were divided into the cardiorenal syndrome groups and the diuretic resistance groups. The serum levels of TNF - α ,IL - 1β ,IL -6 and CRP were detected. Comparison with normal healthy volunteers, to analyse the differences between the three gpoups in inflammatory cytokines. Results：Total 58 patients with type I cardiorenal syndrome were enrolled in this study and 27 healthy volunteers were recruited as control group. Statistical analysis showed that there was a significant difference in inflammatory cytokines between the three gpoups. Conclusion：The inflammatory reaction not only was involved in the pathophysiology of type I cardiorenal syndrome, in the development of diuretic resistance, it also play an important role.