血清MIF水平与缺血性脑卒中关系的meta分析

Meta Analysis on the Relationship Between Serum MIF Level and Ischemic Stroke

目的:综合评价血清巨噬细胞移动抑制因子水平与缺血性脑卒中的关系。方法:分别以"血清巨噬细胞移动抑制因子"与"脑卒中、脑血管病、脑梗死、脑栓塞"其中之一结合以主题或关键词或题名检索中国生物医学文献数据库(CMB)、中国学术期刊全文数据库(CNKI)、万方医学数据库、重庆维普数据库;以"macrophage migration inhibitory factor"或"MIF"与"Stroke"、"Cerebrovascular Disease"、"Cerebral Infarction"、"Cerebral Embolism"其中之一结合检索Medline、Pubmed等外文数据库,收集2014年11月以前国内外公开发表的有关中国人血清巨噬细胞移动抑制因子水平与缺血性脑卒中关系的研究文献。按照纳入与排除标准,共纳入9篇文献进行Meta分析。结果:总体效应检验Z=0.20,P=0.84,均数差(SMD)为0.05,95%CI:-0.45^-0.56。I 2>50%,按颈部动脉硬化有无及病程进展进行亚组分析。分析结果显示,AS亚组均数差(SMD)为0.71,95%CI:0.41~1.00,提示血清巨噬细胞移动抑制因子水平升高可能增加发生缺血性脑卒中的危险;进展亚组均数差(SMD)为-0.65,95%CI:-0.98^-0.33,提示血清巨噬细胞移动抑制因子水平降低可能影响IS的严重程度。结论:血清巨噬细胞移动抑制因子水平与缺血性脑卒中的发生有关,巨噬细胞移动抑制因子可能是缺血性脑卒中炎症反应和病情变化的血清标记物之一。

Objective： o evaluate the relationship between serum MIF level and IS. Methods： Papers about the relationship between serum MIF level and IS published before November 2014 were retrieved and collected from CMB,CNKI,Wang Fang,CQVip,Medline,Pubmed and so on. According to inclusion and exclusion criteria,a total of 9 related papers were suitable for meta- analysis. Results These papers were inhomogeneous and then a random effect modem was used. Overall effect Z was 0. 20（ P = 0. 84）,SMD was 0. 05（ 95% CI：- 0. 45 ^- 0. 56） through meta- analysis. Subgroups analyses were carried out according to the neck atherosclerosis or and progression. SMD was 0. 71（ 95% CI： 0. 41 ~ 1. 00） in AS subgroup and- 0. 65（ 95% CI：- 0. 98 ^- 0. 33） in period subgroup.Conclusion： Serum MIF level was related to IS and selected as one marker to predict inflammation and progress in IS.