足部反射疗法对2型糖尿病大鼠肾脏早期病变的影响

Protective Effect of Foot Reflextherapy on Early Nephropathy of Rats With Type 2 Diabetes

目的:观察足部反射疗法对2型糖尿病大鼠肾脏早期病变的影响。方法:采取高热量饮食加小剂量链脲佐菌素建立2型糖尿病大鼠模型,并随机分为模型组、足疗组、正常组;8周后,检测空腹胰岛素、肾质量/体质量值、24h尿白蛋白、2微球蛋白、肌酐清除率等变化。结果:与正常组相比,模型组空腹胰岛素、肾质量/体质量、24h尿白蛋白、24h尿2微球蛋白、肌酐清除率明显增加(P<0.01);足疗组与模型组比较,体质量/肾质量无显著性差异(P>0.05),其他值均降低(P<0.05)。结论:足部反射疗法可以降低2型糖尿病大鼠的空腹胰岛素、早期尿白蛋白、2-微球蛋白在尿中的排泄,降低尿肌酐清除率,对肾脏具有保护作用,但肾质量/体质量值无作用。

Objective： To evaluate the protective effect of foot reflexotherapy on early nephropathy of the rats with type 2 diabetes.Methods： Murine type 2 diabetic model was induced by high calorie feeding and injection of small dose of streptozotocin and the modeled rats were randomly divided into 2groups： model group,foot reflexotherapy group,and normal rats without any treatment were set as normal control group. After 8weeks,FINS,ratio of kidney weight to body weight,clearance creatinine,24 h total albumin and 24h2- microglobin in urine were determined. Results： It was demonstrated that FINS,ratio of kidney weight to body weight,albumin in24 h urine and beta- 2 microglobin in 24 h urine and clearance creatinine increased significantly in model group when compared with normal group（ P 〈 0. 05）,while the other mentioned Parameters in the foot reflexotherapy group were remarkably decreased as compared with model group（ P 〈 0. 05） except that the ratio of kidney weight to body weight was no statistical difference（ P 〉 0. 05）. Conclusion： Foot reflexology could protect the kidney function in the rats with type 2 diabetes in view of its reducing the FINS,ratio of kidney weight to body weight,the excretion of urine albumin,beta- 2 microglobin,and clearance rate of creatinine.