慢性戊型肝炎相关研究进展

Advances on chronic hepatitis E

戊型肝炎散发于世界各地，多为急性自限性疾病，但近年来不断有文献报道在HIV感染者、器官移植和放化疗患者等免疫力低下人群中发现基因3型戊型肝炎病毒感染导致的戊型肝炎慢性化疾病，其临床表现类似急性戊型肝炎，但症状及肝功能损伤均较轻。目前研究发现，人群感染戊型肝炎病毒后肝炎慢性化的机制主要包括宿主因素和病毒因素。此文就慢性戊型肝炎的定义、临床表现、患者特征、感染慢性化的病毒因素及治疗等方面的进展进行综述。

Hepatitis E is sporadic around the world, which usually is considered as an acute self-limited disease. But in recent years, there are more and more case reports indicate that chronic hepatitis E caused by genotype 3 HEV can be found in patients with compromised immunity related to HIV, organ transplantation and chemotherapy. The clinical manifestations are similar to acute hepatitis E, but the symptoms and the liver dysfunc- tion are slighter. Present research promotes that chronic hepatitis E is related to host factors and viral factors. The definition, clinical manifestations, the characteristics of patients, viral factors of chronic hepatitis E and treatment are reviewed in this article.