G蛋白β3亚基基因多态性与功能性消化不良和肠易激综合征关系的研究进展

Association of G-Protein β3 Subunit Polymorphism with Functional Dyspepsia and Irritable Bowel Syndrome

功能性胃肠病(FGIDs)是一组临床常见消化系统疾病,其病因和发病机制尚不完全清楚,目前认为主要与胃肠动力异常、内脏高敏感等有关。G蛋白是一类细胞内信号转导分子,可介导多种与胃肠动力、内脏感觉相关的细胞内反应,在FGIDs的发病中具有重要意义。研究发现G蛋白β3亚基(GNβ3)基因是与FGIDs易感性相关的候选基因之一,本文对GNβ3基因多态性与功能性消化不良和肠易激综合征关系的研究进展作一综述。

Functional gastrointestinal disorders（ FGIDs） is a group of commonly seen gastrointestinal symptoms with uncertain etiology and pathogenic mechanism,and a link between FGIDs and gastrointestinal dysmotility and visceral hypersensitivity was established. G-Protein is an intracellular signal transduction molecule that mediates various cellular responses related to gastrointestinal motility and visceral perception,and might play an important role in the pathogenesis of FGIDs. Studies showed that G-protein β3 subunit（ GNβ3） gene is one of the candidate genes for susceptibility of FGIDs.In this article,progress in study on GNβ3 polymorphism and its association with functional dyspepsia and irritable bowel syndrome was reviewed.