不同剂量皮硝外敷对胃肠外科术后早期炎性肠梗阻的影响

Effects of External Application of Mirabilite at Different Doses on Early Inflammatory Intestinal Obstruction after Gastrointestinal Surgery

目的:探讨不同剂量皮硝外敷对胃肠外科术后早期炎性肠梗阻的影响。方法:将120腹部手术后出现术后早期炎性肠梗阻患者分为观察组和对照组,其中观察组包括高、中、低3个剂量组,对照组采用常规治疗方案,在对照组基础上观察组应用皮硝外敷,高、中、低3个剂量组皮硝剂量分别为500 g、300 g、50 g;观察并比较两组患者治疗后腹胀缓解时间、排气时间及胃肠减压量;于治疗前及治疗后5d检测并比较两组血清肌酸磷酸激酶(CPK)、血清C反应蛋白(CRP)、血清肿瘤坏死因子-α(TNF-α)、血清白介素-6(IL-6)、内毒素(LPS)水平的差异。结果:高、中、低剂量组及对照组腹胀缓解时间、排气时间逐渐延长,胃肠减压量逐渐增加,组间比较,差异具有统计学意义(P<0.05);治疗后,各组CPK、CPR、IL-6、TNF-α及LPS水平均显著降低,与治疗前比较,差异具有统计学意义(P<0.05);且高、中、低剂量组及对照组上述指标逐渐增高,各组间上述指标比较,差异均具有统计学意义(P<0.05)。结论:500 g剂量皮硝外敷能够明显改善术后早期炎性肠梗阻临床症状及炎症指标。

Objective： To investigate the effects of external application of mirabilite of different doses on early inflammatory intestinal obstruction after gastrointestinal surgery. Methods： A total of 120 ea- ses of early inflammatory intestinal obstruction patients after abdominal operation were divided into ob- servation group and control group, The observation group included high dose , moderate dose and low dose groups, Control group were treated with routine method. On the basis of routine method, the three observation groups were given 500 g, 300 g, 50 g doses of mirabilite respectively. Alleviation time, exhaust time and the amount of gastrointestinal decompression after treatment of the groups were ob- served and compared, Serum creatine phosphokinase （ CPK）, serum C reactive protein （CRP）, ser- um tumor necrosis factor alpha （TNF-alpha）, interleukin-6 （IL-6） and endotoxin （LPS） before treat- ment and after treatment were detected and compared. Results： The alleviation time, exhaust time and gastrointestinal decompression amount of high dose group, middle dose group, low dose group and con- trol group gradually increased, there were statistical difference among the four groups（P 〈0.05）. After treatment, the CPK,CPR,IL-6,TNF-a and LPS of each group decreased significantly, there were statis- tical difference （P 〈 0.05 ）. And the indexes mentioned above of high dose group, middle dose group, low dose group and control group gradually decreased, differences were statistically significant （P 〈 0. 05 ）. Conclusion： External application of 500 g mirabilite can significantly improve clinical symptoms and inflammatory markers of patients with early postoperative inflammatory intestinal obstruction.