精氨酸酶在气道炎症和气道重塑中的作用

The role of arginase in the airway inflammation and airway remodeling

支气管哮喘是可逆性气流受限的慢性气道炎症性疾病,气道炎症的长期存在可引起气道的重塑,但目前关于哮喘气道重塑的发病机制仍未完全阐明。近年来,许多研究发现精氨酸酶在哮喘的气道炎症和气道重塑中发挥着重要作用,其不仅能降低气道释放的NO水平,增加气道高反应性,而且其代谢产物如腐胺、脯氨酸等能诱导细胞的增殖和胶原的合成,导致气道重塑。文中就精氨酸酶及其在哮喘发病中的作用作一综述。

Bronchial asthma is the chronic airway inflammatory disease that characterized by reversible airflow limitation. The presence of airway inflammation could lead to airway remodeling. In recent years,many studies have found that arginase plays an important role in the airway inflammation and airway remodeling of asthma. It not only reduces airway release nitric oxide and increases airway hyperresponsiveness,but also its metabolites such as putrescine,proline,etc can induce cell proliferation and collagen synthesis,leading to airway remodeling. In this paper,the arginase and its role in the pathogenesis of asthma are discussed.