摘要
人体正常的体细胞有23对染色体,DNA含量恒定,在细胞癌变过程中DNA含量增加或减少,即成为非整倍体细胞,是恶性肿瘤的特异性标志。DNA定量分析是通过对细胞核内DNA含量或倍体的检测来判断细胞的生理或病理状态,能客观地反映病损的情况,对肿瘤的早期诊断、筛查、预后判断及疗效评价有重要意义。本文主要就近年来DNA定量分析在口腔癌及癌前病变中的研究进展作一综述。
Normal individual cells had 23 pairs of chromosome and stable DNA content. DNA content was varied during malignant transformation, which was specific feature of tumor. Quantitative DNA analysis can reflect cellular physiological or pathological condition by nuclear DNA content, which had significant role in early diagnosis, predication of prognosis and treatment selection. This article summarized the research progress of quantitative DNA analysis in oral carcinoma and precancerous lesions in recent years.
出处
《上海口腔医学》
CAS
CSCD
2015年第1期124-128,共5页
Shanghai Journal of Stomatology
基金
上海市科学技术委员会科研基金(11DZ1972600)
上海市卫生局基金(ZYSNXD-CC-ZDYJ004)~~
关键词
DNA定量分析
DNA倍体
口腔癌
癌前病变
Quantitative DNA analysis
DNA ploidy
Oral carcinoma
Precancerous lesions
