十二指肠Brunner腺增生

Duodenal Brunner 's Gland Hyperplasia

十二指肠Brunner腺增生发病率较低,其确切病因和发病机制尚不清楚,临床表现缺乏特异性,早期可无明显临床症状和体征,但随着病变体积的增大,可发生出血、梗阻等并发症。近年来,随着内镜技术的广泛应用,Brunner腺增生的检出率明显增高。本文就该病的病因和发病机制、临床表现、诊断和鉴别诊断以及治疗和预后作一综述。

Brunner＇ s gland hyperplasia is a rare lesion in duodenum with uncertain etiology and pathogenic mechanism. The clinical manifestations of these lesions are non-specific, most of them are asymptomatic in their early stage, but cases with a large polyp tend to have gastrointestinal bleeding and obstructive complications. With the widespread use of endoscopy, the detection rate of duodenal Brunner＇ s gland hyperplasia increases in recent years. In this review article, the etiology, pathogenesis, clinical manifestations, diagnosis and differential diagnosis, management and prognosis of the disease were summarized.