荧光素钠应用于荧光素造影检查眼底血管的安全性及不良反应特点

The safety and adverse reactions of fluorescein sodium used in fundus fluorescein angiography

目的观察荧光素钠应用于荧光素眼底血管造影(FFA)检查的安全性及不良反应特点。方法收集2011年3月至2014年3月在我院行FFA检查289例患者,记录所有患者不良反应发生情况,并分析其与患者性别、年龄进行相关性。结果在289例患者中,15例发生不良反应,占5.20%,均为轻、中度不良反应,无死亡病例,以恶心、呕吐的不良反应居多。男性发生率显著高于女性(P<0.01);40岁以下的发生率较高。结论在眼底血管造影时应用荧光素钠,是相对安全的。不良反应发生率低,均为轻、中度,死亡病例及严重不良反应极少。而不良反应中产生呕吐的原因可能是强烈的迷走神经反应。男性及中青年人发生率明显增加,可能在于男性及中青年人迷走神经兴奋性高,遇到不良刺激后,精神紧张而容易发生一些不良反应。

Objective To observe the safety and adverse reactions of fluorescein sodium used in fundus fluorescein angingraphy. Methods Reviewed medical history of 289 patients who underwent fundus fluorescein angiography examina- tion between March 2011 and March 2014 in our hospital. Occurrence of adverse reactions was recorded and its relationship to gender and age was analyzed. Results In 289 patients, there were 15 patients had adverse reactions （ 5.2% ）. All ad- verse reactions were mild to moderate. No death was caused. The major clinical features of adverse reactions included nau- sea and vomiting. Incidence rate was significantly greater than in male than in female { P 〈0.01 ~, and higher in patients under 40 years of age than in patients over 40 years of age. Conclusion Fluoreseein sodium used in fundus fluoroscein an- giography examination is relatively safe. Incidence of adverse reactions was low, and the reactions were mild to moderate. Death and serious adverse reactions are rare. Vomiting may be due to vagal reaction. The incidence is higher in males and in young people, consistent with the fact that vagal nerve excitability is higher in men and young people.