睑缘炎患者泪膜功能的临床观察

Clinical observation of the tear film in patients with blepharitis

目的观察睑缘炎患者的泪膜功能。方法随机选取2013年3月至2014年1月于我院就诊的睑缘炎患者39例(72只眼),以及正常体检者37例(74只眼)。所有患者均接受泪河高度、泪膜破裂时间、角膜荧光素染色和基础泪液分泌实验等检查,并将所得检查结果进行统计学分析。结果睑缘炎组患者的泪膜破裂时间为(7.43±2.77)s,显著低于对照组(14.32±6.14)s(P<0.05);睑缘炎组和对照组的角膜荧光素染色评分分别为(1.02±0.69)分和(0.61±0.43)分,差异有显著统计学意义(t=-2.97,P=0.01);泪河高度和基础泪液分泌实验显示两组差异均无统计学意义(P>0.05)。结论睑缘炎患者基础泪液分泌功能正常,但泪膜稳定性降低,是蒸发过强型干眼的易患人群。

Objective To observe the function of tear film in patients with blepharitis. Methods From 2013 June to 2014 January, 72 eyes of 39 patients with blepharltis and 74 normal eyes of 37 people were enrolled in our study. All subjects were examined for the tear meniscus height, break up time, corneal fluorescein staining, and basal tear secre- tion test. The results were statistically analyzed. Results Break up time of the blepharitis group was 7.43 ± 2.77 seconds, significantly lower than 14.32±6.14 seconds in control group （ P 〈0.05）. The scores of corneal fluorescein staining in the blepharitis group and control group were 1.02 ±0. 69 and 0. 61±0. 43 respectively, and the difference was significant （ t = - 2.97, P =0. 01 ）. The tests of tear meniscus height and basal tear secretion showed that there were no signifieant differences between the two groups. Conclusion The function of tear secretion in patients with blepharitis was normal, but the stability of tear film was reduced. Therefore, patients with blepharitis were susceptible to the over evaporative dry eye.