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透明质酸钠凝胶在腹、盆腔术后粘连预防中的应用 被引量:4

The preventive effect of hyaluronic acid on post-surgical pelvic and abdominal adhesion
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摘要 目的 观察透明质酸钠凝胶在妇科腹、盆腔术后粘连预防中的临床疗效.方法 336例拟行妇产科腹、盆腔手术患者,对患者及医生采用双盲法,随机将其分为观察组172例,对照组164例;对照组常规处置,观察组在对应区域的腹膜上涂抹透明质酸钠凝胶,并在术后应用透明质酸钠凝胶涂抹创面.观察两组术后粘连率和手术前后血清CRP水平.结果 两组患者术后粘连率(47.5%比19.8%)差异有统计学意义(x2=13.10,P<0.01);两组术后CRP水平差异有统计学意义[(24.5 ±3.4)mg/L比(12.7±3.9) mg/L(t=20.86,P<0.01)].结论 透明质酸钠凝胶应用于妇科腹、盆腔手术术后粘连的预防中效果良好,可显著改善血清炎性因子水平. Objective To explore the clinical effect of sodium hyaluronic acid on prevention of post-surgical pelvic and abdominal adhesion in gynecology.Methods 336 patients with pelvic and abdominal operation,using the double blind method for the patients and doctors,were randomly divided into the observation group (172 cases)and control group(164 cases).The experimental group was given hyaluronic acid in corresponding regions of the peritoneum,and the control group was not given any tissue adhesion prevention measures.Postoperative adhesions incidence and the change of serum CRP level of two groups were recorded.Results There was significant difference between the two groups in postoperative adhesions incidence (47.5% vs 19.8%,x2 =13.10,P 〈 0.01).The CRP level of the observation group changed significantly as compared with the control group after operation [(24.5 ±3.4)mg/L vs(12.7 ±3.9)mg/L(t =20.86,P〈0.01)].Conclusion Hyaluronic acid in prevention of postoperative adhesion of pelvic and abdominal operation is effective on improving the serum level of inflammatory factors.
作者 胡旦红 刘芳
出处 《中国基层医药》 CAS 2015年第3期332-333,共2页 Chinese Journal of Primary Medicine and Pharmacy
基金 吴阶平医学基金会临床科研专项资助基金项目
关键词 粘连 透明质酸 Adhesions Hyaluronic acid
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