血细胞计数与冠状动脉慢血流现象的相关性研究

The effect of blood cell count on coronary flow in patients with coronary slow flow phenomenon

目的 研究冠状动脉慢血流观象（CSFP）患者血细胞计数及其与冠状动脉速率的关系.方法 入选冠脉造影患者3 368例,并对其进行TIMI帧数分析,其中78例患者出现CSFP（观察组）,与61例冠状动脉正常血流患者（对照组）在基本特征及实验室检查方面进行比较分析.结果 两组患者基本特征相似,CSFP患者平均校正的TIMI血流帧数（cTFC）明显升高（P＜0.001）,此外,CSFP患者红细胞比容、血红蛋白值,嗜酸性粒细胞和嗜碱性粒细胞计数较对照组显著升高（P=0.005,P=0.047,P=0.001,P=0.002）.观察红细胞比容和嗜酸性粒细胞水平增加表明,其与增加帧数具有显著的相关性（r=0.288和r=0.217）.结论 CSFP与冠状动脉正常血流患者比较,其血细胞成分差别较大,红细胞比容、嗜酸性粒细胞和嗜碱性粒细胞的增加直接或间接的对冠状动脉血流速率产生影响.

Objective The coronary slow flow phenomenon （CSFP） is a coronary artery disease with a benign course,but its pathological mechanisms are not yet fully understood.The purpose of this controlled study was to investigate the cellular content of blood in patients diagnosed with CSFP and the relationship of this with coronary flow rates.Methods Coronary angiographies of 3368 patients were selected to assess thrombolysis in myocardial infarction （TIMI） frame count （TFC） values.Seventy eight of them had CSFP,and their demographic and laboratory findings were compared with 61 patients with normal coronary flow.Results Patients＆#39;demographic characteristics were similar in both two groups.Mean corrected TFC （cTFC） values were significantly elevated in CSFP patients （P 〈 0.001）.Furthermore,hematocrit and hemoglobin values,and eosinophil and basophil counts of the CSFP patients were significantly elevated compared with the values obtained in the control group （P =0.005,P =0.047,P =0.001 and P =0.002）.The increase observed in hematocrit and eosinophil levels showed significant correlations with increased TFC values （r =0.288 and r =0.217）.Conclusion Significant changes have been observed in the cellular composition of blood in patients diagnosed with CSFP as compared to the patients with normal coronary blood flow.The increases inhematocrit levels and in the eosinophil and basophil counts may have direct or indirect effects on the rate of coronary blood flow.