奥美拉唑联合抗生素治疗胃溃疡疗效观察

Clinical effect of omeprazole combined with antibiotics in the treatment of peptic ulcer

目的 探讨奥美拉唑和抗生素联合应用治疗胃溃疡的疗效及不良反应.方法 回顾性分析2013年3月至2014年3月接受治疗的胃溃疡患者92例,按照治疗方法分为观察组与对照组,各46例,对照组给予西咪替丁、阿莫西林联合甲硝唑治疗;观察组给予奥美拉唑、阿莫西林联合甲硝唑治疗,分析两组的临床疗效及不良反应发生情况.结果 观察组患者治疗后临床有效率为93.48％,高于对照组的78.26％,两组差异有统计学意义（x2=8.930,P＜0.05）.观察组患者治疗后胃部灼烧感、腹胀评分明显优于对照组,两组比较差异均有统计学意义（t=7.42、8.03,均P＜0.05）.结论 奥美拉唑联合抗生素治疗胃溃疡临床疗效明显,且安全可靠,值得临床推广应用.

Objective To explore the efficacy and adverse reaction of combined application of omeprazole and antibiotics in treatment of peptic ulcer.Methods 92 peptic ulcer patients in our hospital from 2013 March to 2014 March were selected.According to treatment methods,they were divided into the observation group and control group,46 cases in each group.The control group was given cimetidine,amoxicillin metronidazole treatment;the observation group was given omeprazole,amoxicillin and metronidazole treatment.The clinical efficacy and adverse reactions of the two groups were analyzed.Results The clinical efficacy of the observation group after treatment was 93.48 %,which was significantly higher than 78.26% of the control group （x2 =8.930,P 〈 0.05）.The abdominal distention,stomach burning sensation grades of the observation group were significantly better than the control group （t =7.42,8.03,P 〈 0.05）.Conclusion The combined application of omeprazole and antibiotics has obvious effect in treatment of ulcer disease,and it is safe and reliable,which is worthy of clinical application.