血清降钙素原检验在呼吸系统感染治疗中的临床价值

Clinical value of serum rrocalcitonin levels test on respiratory system infection

目的 研究血清降钙素原水平检验在呼吸系统感染治疗中的临床意义.方法 选择呼吸系统感染患者80例作为观察组,根据患者感染严重程度将观察组分为普通感染组（40例）和严重感染组（40例）.另选取同期健康志愿者40例为对照组.比较三组呼吸系统感染严重程度与APACHE-Ⅱ评分及血清降钙素原的关系、治疗前后血清降钙素原的变化.结果 对照组、普通感染组、严重感染组患者血清降钙素原水平分别为（0.34±0.06）、（17.54±6.01）、（68.51±13.42）μg/L,APACHE-Ⅱ评分分别为0、（3.22±1.92）、（24.45±6.32）分.严重感染组患者血清降钙素原水平明显高于普通感染组和对照组,组间比较差异有统计学意义（t =3.35,3.48,P均＜0.05）;普通感染组患者血清降钙素原水平明显高于对照组,组间比较差异有统计学意义（t =3.26,P＜0.05）.严重感染组患者APACHE-Ⅱ评分明显高于普通感染组,组间比较差异有统计学意义（t =3.67,P＜0.05）.呼吸系统感染患者血清降钙素原水平及APACHE-Ⅱ评分均随患者感染程度的增加而升高,两者呈正相关（t =3.52,3.47,P＜0.05）.观察组患者治疗前及治疗后与对照组患者血清降钙素原水平比较差异有统计学意义（t=3.58,3.41,P＜0.05）,观察组患者治疗前血清降钙素原水平与治疗后及对照组比较,差异有统计学意义（t=3.50,3.49,P＜0.05）.结论 血清降钙素原水平与呼吸系统感染程度呈正比,可用于判断患者治疗的临床疗效及预后情况,对呼吸系统感染的治疗具有指导作用.

Objective To study the clinical significance of the serum procalcitonin levels test in the treatment of respiratory system infection.Methods Chose 80 cases patients with respiratory system infection as the research object,for the observation group,according to the severity of infection in patients with the observation group was divided into general infection group（40 cases） and severe infection group （40 cases）.Healthy volunteers were selected for the control group of 40 cases.Compared the three groups of patients with respiratory system infection and the severity of APACHE-Ⅱ score and serum calcitonin,before and after the treatment of the relationship between the changes of serum procalcitonin.Results In the control group,the common infection group,severe infection serum procalcitonin levels were（0.34 ±0.06）,（17.54 ± 6.01）,（68.51 ± 13.42） μg/L,APACHE-Ⅱ score was 0 points,（3.22 ± 1.92）,（24.45 ±6.32） points.Severe infection serum procalcitonin levels were significantly higher than the general infection group and control group,there was significant difference between the two groups （t =3.35,3.48,P 〈 0.05） ; Serum group were general infection procalcitonin levels,were significantly higher than those in the control group,significant differences also exist between the two groups（t =3.26,P 〈 0.05）.Serious infection group were significantly higher than in the general score of APACHE-Ⅱ infection group,there was significant difference between the two groups （t =3.67,P 〈 0.05）.Procalcitonin levels and APACHE-Ⅱ score increased with the increased degree of infection in patients with increased in serum of patients with respiratory system infection,they were positively correlated （t =3.52,3.47,P 〈 0.05）.Compared with the observation group patients before and after treatment,the serum procalcitonin levels in control group were significant different（t =3.58,3.41,P 〈0.05）,the patients in observation group before treatment,the levels of serum procalcitonin and after treatment and the control group,the difference had statistical significance（t =3.50,3.49,P 〈0.05）.Conclusions The levels of serum procalcitonin and respiratory infection is proportional to the degree,it can be used to judge the clinical curative effect and the prognosis of patients,and has a guiding role for the treatment of respiratory infection.