感染表型慢性阻塞性肺疾病

Infective phenotype chronic obstructive pulmonary disease

COPD是一种慢性炎症性病变，可累及大小气道、肺实质以及肺血管。引起COPD的危险因素众多，其中下呼吸道感染，尤其是细菌感染是导致COPD发生及急性加重的一个重要原因，以至有学者提出一个全新概念——感染表型COPD。本文拟对感染表型COPD概念提出背景及感染表型COPD的特征作一综述。

Chronic obstructive pulmonary disease （COPD） is a chronic inflammatory disease which involved large/small airways, pulmonary parenchyma and vessels. Many risk factors can cause COPD, including lower respiratory tract infection and especially bacterial infection in lower respiratory tract is an important cause to lead to COPD and acute exacerbation of COPD. Based on this, some investigators present a new concept infective phenotype COPD. This review focuses on the background of presenting this new concept of infective phenotype COPD and discusses the characteristics of this kind of COPD.